结肠切除术对溃疡性结肠炎患者胆汁成分、胆固醇晶体形成及胆结石的影响。
Effect of colectomy on bile composition, cholesterol crystal formation, and gallstones in patients with ulcerative colitis.
作者信息
Harvey P R, McLeod R S, Cohen Z, Strasberg S M
机构信息
Samuel Lunenfield Research Institute, University of Toronto, Ontario, Canada.
出版信息
Ann Surg. 1991 Oct;214(4):396-401; discussion 401-2. doi: 10.1097/00000658-199110000-00004.
Abstract
Bile composition and the presence of cholesterol crystals in bile were studied in bile samples obtained at the time of surgery in patients with ulcerative colitis. Some patients were sampled before colectomy and others at a second operation months to years after a colectomy. Patients in the precolectomy group were found to have bile composition similar to control patients without gallstones, and few had crystals in their bile. In the postcolectomy group, cholesterol concentrations were very high, all biles were supersaturated, and almost all patients had cholesterol crystals in their bile. These findings are similar to those found in persons with cholesterol gallstones. Twenty patients have been followed for at least 3 years after colectomy and to date three have formed cholesterol gallstones.
摘要
对溃疡性结肠炎患者手术时获取的胆汁样本进行了胆汁成分及胆汁中胆固醇结晶情况的研究。部分患者在结肠切除术之前取样，其他患者则在结肠切除术后数月至数年的二次手术时取样。发现结肠切除术前组患者的胆汁成分与无胆结石的对照患者相似，且胆汁中几乎没有结晶。在结肠切除术后组中，胆固醇浓度非常高，所有胆汁均呈过饱和状态，几乎所有患者的胆汁中都有胆固醇结晶。这些发现与胆固醇胆结石患者的情况相似。20名患者在结肠切除术后至少随访了3年，迄今为止已有3人形成了胆固醇胆结石。
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