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[肿瘤放射病理形态学诊断中的核DNA含量及细胞有丝分裂情况]

[The nuclear DNA content and cellular mitotic regimen in the diagnosis of the radiation pathomorphosis of tumors].

作者信息

Modiaev V P, Zobnina M N, Dikovich M F

出版信息

Arkh Patol. 1991;53(8):14-6.

PMID:1953370
Abstract

Histological material from 26 patients with laryngeal carcinoma was studied after surgery, photon and remote neutron-photon irradiation. The number of telophases in dividing tumor cells after the mixed irradiation was 1.5-3 times lower as compared to the surgical treatment. This correlated with a significant decrease of the number of cells with high ploidy. It is suggested that the damage to cell cycle occurred after the spin formation, that the parameters studied are sensitive morphological criteria for the diagnosis and prognosis of the tumor cell fate.

摘要

对26例喉癌患者手术后经光子及远距离中子 - 光子照射的组织学材料进行了研究。与手术治疗相比,混合照射后肿瘤分裂细胞中的末期数量降低了1.5至3倍。这与高倍体细胞数量的显著减少相关。提示在纺锤体形成后细胞周期发生了损伤,所研究的参数是肿瘤细胞命运诊断和预后的敏感形态学标准。

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