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1例托吡酯诱发鼻出血的病例。

A case of topiramate-induced epistaxis.

作者信息

Polimeni Giovanni, Grugno Rosario, Vitetta Antongiulio, Cordici Francesco, Alagna Antonella, Caputi Achille P, Bramanti Placido

机构信息

Istituto di Ricovero e Cura a Carattere Scientifico Centro Neurolesi Bonino-Pulejo, S.S. 113, Via Palermo, C.da Casazza, 98124, Messina - Italy.

出版信息

Curr Drug Saf. 2009 Sep;4(3):207-8. doi: 10.2174/157488609789007001. Epub 2009 Sep 1.

DOI:10.2174/157488609789007001
PMID:19534643
Abstract

The current case describes epistaxis in a patient treated with a daily regimen of topiramate 100mg for migraine. The patient had not a past medical history of nosebleeds and laboratory parameters were within normal ranges. She was then advised to withdraw topiramate, and the epistaxis resolved within 12 hours after its discontinuation. Since then, the patient never complained other blood clotting disorders. The potential antiplatelet activity of topiramate is discussed.

摘要

本病例描述了一名偏头痛患者，每日服用100毫克托吡酯进行治疗，出现鼻出血。该患者既往无鼻出血病史，实验室检查参数均在正常范围内。随后建议患者停用托吡酯，停药后12小时内鼻出血症状缓解。此后，该患者再未出现其他凝血功能障碍。文中讨论了托吡酯潜在的抗血小板活性。

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