College of Pharmacy, Liaoning University of Traditional Chinese Medicine, DD Port, Dalian Economic and Technical Development Zone, 116600 Dalian, China.
Fitoterapia. 2009 Jun;80(4):219-22. doi: 10.1016/j.fitote.2009.01.011. Epub 2009 Feb 1.
A new compound, named quinquefoloside-L(c) (1), together with nine known compounds, was isolated from leaves of Panax quinquefolium, and its structure was elucidated as 3beta,12beta, 20S-trihydroxy-25-methoxydammar-23-ene 3-O-beta-D-glucopyranosyl (1-->2)beta-D-glucopyranosyl-20-O-beta-D-xylopyanosyl (1-->6) beta-D-glucopyranoside (1), on the basis of MS, 1D-and 2D-NMR experiments as well as by chemical degradation. The cytotoxicity of these compounds against human breast cancer MCF-7 cell line was also tested by MTT method.
从西洋参叶片中分离得到一个新的化合物，命名为 quinquefoloside-L(c)(1)，同时还分离得到了另外 9 个已知化合物，其结构被鉴定为 3β,12β,20S-三羟基-25-甲氧基达玛-23-烯 3-O-β-D-吡喃葡萄糖基(1→2)β-D-吡喃葡萄糖基-20-O-β-D-木吡喃糖基(1→6)β-D-吡喃葡萄糖苷(1)。基于 MS、1D 和 2D-NMR 实验以及化学降解，对这些化合物进行了测试。这些化合物对人乳腺癌 MCF-7 细胞系的细胞毒性也通过 MTT 法进行了测试。
