Clancy R L, Cripps A W, Gebski V
Royal Newcastle Hospital, NSW.
Med J Aust. 1990 Apr 16;152(8):413-6. doi: 10.5694/j.1326-5377.1990.tb125268.x.
Subjects prone to recurrent acute bronchitis were admitted to a six-month double-blind clinical study, in which the value of oral immunization with a preparation of killed Haemophilus influenzae was tested. Most subjects had early smoking-related chronic lung disease, unrecognized by either the patient or his/her doctor. Subjects taking the active agent had a 41% reduction in the total number of episodes of acute bronchitis (P = 0.16), a 60% reduction in the number of episodes of acute wheezy bronchitis (P = 0.02) and a 58% reduction in antibiotic use (P = 0.07). The power of analysis was restricted by the small study group. Parameters of episode severity favoured the test group, suggesting that individual episodes of acute bronchitis in subjects taking an oral preparation of killed H. influenzae were less severe than in those taking placebo tablets. Oral immunization with H. influenzae selectively reduced the increase in colonization of the oropharynx with H. influenzae which occurred in the group taking placebo. This is the first demonstration that the common mucosal system can be activated to modify a colonization pattern at a distant site.
易患复发性急性支气管炎的受试者被纳入一项为期六个月的双盲临床研究，该研究测试了用灭活流感嗜血杆菌制剂进行口服免疫的效果。大多数受试者患有早期与吸烟相关的慢性肺病，但患者本人及其医生均未意识到。服用活性剂的受试者急性支气管炎发作总数减少了41%（P = 0.16），急性喘息性支气管炎发作次数减少了60%（P = 0.02），抗生素使用量减少了58%（P = 0.07）。分析效能受到研究小组规模较小的限制。发作严重程度参数有利于试验组，这表明服用灭活流感嗜血杆菌口服制剂的受试者的急性支气管炎单次发作比服用安慰剂片的受试者症状较轻。用流感嗜血杆菌进行口服免疫选择性地减少了服用安慰剂组中出现的流感嗜血杆菌在口咽部定植的增加。这是首次证明共同黏膜系统可被激活以改变远处部位的定植模式。
