PPARγ2基因中脯氨酸12被丙氨酸替代与男性冠状动脉疾病范围扩大有关。
The proline 12 alanine substitution in the PPARgamma2 gene is associated with increased extent of coronary artery disease in men.
作者信息
Schneider J G, Schiekofer S, von Eynatten M, Schlimmer P, Dugi K A
机构信息
Department of Medicine, Washington University in St. Louis, Campus Box 8069, St. Louis, MO 63110, USA.
出版信息
Exp Clin Endocrinol Diabetes. 2009 Oct;117(9):519-21. doi: 10.1055/s-0029-1216351. Epub 2009 Jun 17.
OBJECTIVE
To determine whether there is an independent association between the Pro12Ala polymorphism in the peroxisome proliferator-activated-receptor gamma2 (PPARgamma2)-gene and the extent of coronary artery disease in men.
RESEARCH DESIGN AND METHODS
We determined the Pro12Ala polymorphism in the PPARgamma2 gene in 240 male patients undergoing elective coronary angiograpy, and quantitated the degree of CAD by evaluating the extent-score which better correlates with known risk factors than other measures of CAD.
RESULTS
The presence of the 12Ala allele was significantly associated with higher CAD extent (r=0.27, p<0.01). CAD extent was also correlated with the extent of insulin resistance (HOMA, r=0.22, p<0.01), and age (r=0.16, p<0.05). Multivariate analysis revealed an independent association between the 12Ala allele PPARgamma2 with extent-score (beta=0.32, p<0.01).
CONCLUSIONS
The 12Ala allele in PPARgamma2 correlates with a significantly increased CAD extent in men, which suggest that lower activity of the transcription factor PPARgamma2 is associated with more severe CAD.
目的
确定过氧化物酶体增殖物激活受体γ2（PPARγ2）基因中的Pro12Ala多态性与男性冠状动脉疾病程度之间是否存在独立关联。
研究设计与方法
我们测定了240例接受择期冠状动脉造影的男性患者PPARγ2基因中的Pro12Ala多态性，并通过评估范围评分来量化冠状动脉疾病（CAD）的程度，该评分与已知风险因素的相关性比CAD的其他测量方法更好。
结果
12Ala等位基因的存在与更高的CAD程度显著相关（r = 0.27，p < 0.01）。CAD程度也与胰岛素抵抗程度（HOMA，r = 0.22，p < 0.01）和年龄（r = 0.16，p < 0.05）相关。多变量分析显示PPARγ2的12Ala等位基因与范围评分之间存在独立关联（β = 0.32，p < 0.01）。
结论
PPARγ2中的12Ala等位基因与男性CAD程度显著增加相关，这表明转录因子PPARγ2的活性降低与更严重的CAD相关。
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