Ji-Rong Yue, Bi-Rong Dong, Chang-Quan Huang, Zhen-Chan Lu, Hong-Mei Wu, Yan-Ling Zhang, Mattis Tod A
Department of Geriatrics, West China Hospital, Sichuan University, Sichuan, China.
Arch Med Res. 2009 Jul;40(5):411-5. doi: 10.1016/j.arcmed.2009.05.005. Epub 2009 Jul 26.
The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPARgamma) has been associated with decreased obesity, insulin resistance, type 2 diabetes and other age-associated diseases such as cognitive impairment, hypertension, cancer, osteoarthritis. Each one of these diseases had been linked to depression. Moreover, there is also an association between Pro12 Ala polymorphism in PPAR gamma2 and longevity. The aim of the study was to evaluate the association between Pro12 Ala polymorphism and depression in Chinese nonagenarians and centenarians.
The sample included 697 unrelated Chinese nonagenarians/centenarians (aged between 90-108 years, mean age: 93.5+/-3.35 years; 67.2% women). The Pro12Ala variant was examined using polymerase chain reaction-restriction fragment length polymorphism. Depression was measured with brief 23-item Geriatrics Depression Scale Chinese-edition (GDS-CD).
In this sample, the genotype frequencies of the Pro12Ala polymorphism were 0% Ala12Ala, 9.2% Pro12Ala, 90.8% Pro12Pro and the prevalence of depression was 25.3%. Subjects who were 12Ala carriers had significantly lower prevalence of depression than those who were not 12Ala carriers (14.06 vs. 26.38%, p=0.034). Subjects without depression also had a higher frequency of 12Ala gene than those with depression (5.28 vs. 2.56%, p=0.031). Adjusting for certain clinical factors that may be associated with depression or with 12Ala carriers, multiple logistic regressions showed the 12Ala gene was associated with decreased incidence of depression.
In summary, we found that among Chinese nonagenarians and centenarians, the Pro12Ala polymorphism in PPARgamma2 was associated with depression and that the 12Ala gene may be a factor for decreased depression.
过氧化物酶体增殖物激活受体γ（PPARγ）的Pro12Ala多态性与肥胖、胰岛素抵抗、2型糖尿病以及其他与年龄相关的疾病如认知障碍、高血压、癌症、骨关节炎的发病率降低有关。上述每种疾病均与抑郁症相关。此外，PPARγ2中的Pro12 Ala多态性与长寿也存在关联。本研究旨在评估中国非agenarians和百岁老人中Pro12 Ala多态性与抑郁症之间的关联。
样本包括697名无血缘关系的中国非agenarians/百岁老人（年龄在90 - 108岁之间，平均年龄：93.5±3.35岁；女性占67.2%）。采用聚合酶链反应 - 限制性片段长度多态性方法检测Pro12Ala变异。使用23项简易中文版老年抑郁量表（GDS - CD）测量抑郁情况。
在该样本中，Pro12Ala多态性的基因型频率为0% Ala12Ala、9.2% Pro12Ala、90.8% Pro12Pro，抑郁症患病率为25.3%。12Ala携带者的抑郁症患病率显著低于非12Ala携带者（14.06%对26.38%，p = 0.034）。无抑郁症的受试者12Ala基因频率也高于有抑郁症的受试者（5.28%对2.56%，p = 0.031）。在对可能与抑郁症或12Ala携带者相关的某些临床因素进行校正后，多因素逻辑回归显示12Ala基因与抑郁症发病率降低相关。
总之，我们发现在中国非agenarians和百岁老人中，PPARγ2中的Pro12Ala多态性与抑郁症相关，且12Ala基因可能是抑郁症发病率降低的一个因素。
