Newsom-Davis Thomas, Poulter Daniel, Gray Rebecca, Ameen Mohammed, Lindsay Iain, Papanikolaou Kyriakos, Butler-Manuel Simon, Christmas Timothy, Townsend Peter, Seckl Michael
Department of Medical Oncology, Imperial College School of Medicine, Charing Cross Hospital, London, UK.
BMC Cancer. 2009 Jun 18;9:195. doi: 10.1186/1471-2407-9-195.
Teratomas are the commonest germ cell tumours and are most frequently found in the testes and ovary. Extragonadal teratomas are rare and mainly occur in midline structures. Uterine teratomas are extremely rare with only a few previous case reports, usually involving mature teratomas of the uterine cervix.
We report an 82-year-old lady presenting with post-menopausal bleeding. Initial investigations revealed a benign teratoma of the uterus which was removed. Her symptoms persisted and a recurrent, now malignant, teratoma of the uterine corpus was resected at hysterectomy. Six months after surgery she relapsed with para-aortic lymphadenopathy and was treated with a taxane, etoposide and cisplatin-containing chemotherapy regimen followed by retroperitoneal lymph node dissection.
In this report we discuss the aetiology, diagnosis and management of uterine teratomas, and review previous case studies.
畸胎瘤是最常见的生殖细胞肿瘤，最常发生于睾丸和卵巢。性腺外畸胎瘤罕见，主要发生于中线结构。子宫畸胎瘤极为罕见，仅有少数既往病例报告，通常为宫颈成熟畸胎瘤。
我们报告一位82岁绝经后出血的女性。初步检查发现子宫良性畸胎瘤并予以切除。她的症状持续存在，子宫体复发性、现已是恶性的畸胎瘤在子宫切除术中被切除。术后6个月，她出现主动脉旁淋巴结病复发，接受了含紫杉烷、依托泊苷和顺铂的化疗方案治疗，随后进行了腹膜后淋巴结清扫术。
在本报告中，我们讨论了子宫畸胎瘤的病因、诊断和管理，并回顾了既往病例研究。
