Jin Jun, Wang Ying, Yang Congqiao, Hu Jicheng, Liu Weizhi, Cui Jian, Tang Xiaoyan
College of Environmental Science and Engineering, Peking University, 100087 Beijing, PR China.
Environ Int. 2009 Oct;35(7):1048-52. doi: 10.1016/j.envint.2009.05.006. Epub 2009 Jun 21.
Polybrominated diphenyl ethers (PBDEs) have been produced in the south coast area of Laizhou Bay, Shandong Province in China, but little is known about the PBDE exposure level of residents to these compounds. We set out to assess potential health risks of PBDEs in the south coast area of the Laizhou Bay by determining the concentrations of PBDEs in serum and breast milk. We measured concentrations of eight PBDE congeners in serum and breast milk. The arithmetic means of Sigma(8)PBDE in pooled serum and breast milk were 613 ng/g lipid and 81.5 ng/g lipid, respectively. The highest concentration for Sigma(8)PBDE in all serum pools was 1830 ng/g lipid from the 41-50 year old female group. BDE-209 was the predominant congener, with the mean concentrations of 403 ng/g lipid in serum and 45.6 ng/g lipid in breast milk, respectively. BDE-209 averagely accounted for 65.8% and 54.2% of the total PBDEs, respectively. Our results suggest that high exposures to PBDEs have led to very high PBDE concentrations in serum and breast milk from the residents living in the south coast area of Laizhou Bay. High PBDE concentrations in human serum, particularly in women, pose a potential public health threat to local residents.
多溴二苯醚（PBDEs）在中国山东省莱州湾南岸地区生产，但居民对这些化合物的PBDEs暴露水平知之甚少。我们通过测定血清和母乳中PBDEs的浓度，评估莱州湾南岸地区PBDEs的潜在健康风险。我们测量了血清和母乳中8种PBDE同系物的浓度。混合血清和母乳中Σ(8)PBDE的算术平均值分别为613 ng/g脂质和81.5 ng/g脂质。所有血清样本中Σ(8)PBDE的最高浓度为来自41 - 50岁女性组的1830 ng/g脂质。BDE - 209是主要同系物，血清中平均浓度为403 ng/g脂质，母乳中为45.6 ng/g脂质。BDE - 209分别平均占总PBDEs的65.8%和54.2%。我们的结果表明，高暴露于PBDEs导致莱州湾南岸地区居民血清和母乳中PBDEs浓度极高。人血清中高浓度的PBDEs，尤其是在女性中，对当地居民构成潜在的公共卫生威胁。
