Laboratory of Molecular Toxicology, MRC Center and College of Pharmacy, Pusan National University, San 30, Jangjeon-dong, Geumjeung-gu, Busan 609-735, South Korea.
Chemosphere. 2012 Mar;87(1):97-104. doi: 10.1016/j.chemosphere.2011.11.074. Epub 2012 Jan 9.
Polybrominated diphenyl ethers (PBDEs), commonly used flame retardants, have been reported as potential endocrine disruptor and neurodevelopmental toxicants, thus giving rise to the public health concern. The goal of this study was to investigate the relationship between umbilical cord blood, maternal blood, and breast milk concentrations of PBDEs in South Korean. We assessed PBDE levels in paired samples of umbilical cord blood, maternal blood, and breast milk. The levels of seven PBDE congeners were measured in 21 paired samples collected from the Cheil Woman's Hospital (Seoul, Korea) in 2008. We also measured thyroid hormones levels in maternal and cord blood to assess the association between PBDEs exposure and thyroid hormone levels. However, there was no correlation between serum thyroxin (T4) and total PBDEs concentrations. The total PBDEs concentrations in the umbilical cord blood, maternal blood, and breast milk were 10.7±5.1 ng g(-1) lipid, 7.7±4.2 ng g(-1) lipid, and 3.0±1.8 ng g(-1) lipid, respectively. The ranges of total PBDE concentrations observed were 2.28-30.94 ng g(-1) lipid in umbilical cord blood, 1.8-17.66 ng g(-1) lipid in maternal blood, and 1.08-8.66 ng g(-1) lipid in breast milk. BDE-47 (45-73% of total PBDEs) was observed to be present dominantly in all samples, followed by BDE-153. A strong correlation was found for major BDE-congeners between breast milk and cord blood or maternal blood and cord blood samples. The measurement of PBDEs concentrations in maternal blood or breast milk may help to determine the concentration of PBDEs in infant.
多溴二苯醚（PBDEs）是一种常用的阻燃剂，被报道为潜在的内分泌干扰物和神经发育毒物，因此引起了公众健康关注。本研究的目的是探讨韩国脐带血、产妇血和母乳中 PBDEs 浓度之间的关系。我们评估了 21 对来自 Cheil 妇女医院（韩国首尔）的脐带血、产妇血和母乳样本中的 PBDE 水平。我们还测量了产妇和脐带血中的甲状腺激素水平，以评估 PBDE 暴露与甲状腺激素水平之间的关系。然而，血清甲状腺素（T4）与总 PBDE 浓度之间没有相关性。脐带血、产妇血和母乳中的总 PBDE 浓度分别为 10.7±5.1ng/g 脂质、7.7±4.2ng/g 脂质和 3.0±1.8ng/g 脂质。脐带血中总 PBDE 浓度的范围为 2.28-30.94ng/g 脂质，产妇血中为 1.8-17.66ng/g 脂质，母乳中为 1.08-8.66ng/g 脂质。在所有样本中，BDE-47（占总 PBDEs 的 45-73%）是主要存在的，其次是 BDE-153。母乳和脐带血或产妇血和脐带血样本之间主要 BDE 同系物之间存在很强的相关性。测量产妇血或母乳中的 PBDEs 浓度可能有助于确定婴儿体内 PBDEs 的浓度。
