高碳水化合物/低脂肪饮食与低碳水化合物/高单不饱和脂肪饮食对1型糖尿病患者餐后甘油三酯浓度及其他心血管危险因素的影响。
Effects of a diet higher in carbohydrate/lower in fat versus lower in carbohydrate/higher in monounsaturated fat on postmeal triglyceride concentrations and other cardiovascular risk factors in type 1 diabetes.
作者信息
Strychar Irene, Cohn Jeffrey S, Renier Geneviève, Rivard Michèle, Aris-Jilwan Nahla, Beauregard Hugues, Meltzer Sara, Bélanger André, Dumas Richard, Ishac Alain, Radwan Farouk, Yale Jean-François
机构信息
Research Center of the University of Montreal Hospital Center, Montreal, Quebec, Canada.
出版信息
Diabetes Care. 2009 Sep;32(9):1597-9. doi: 10.2337/dc08-2322. Epub 2009 Jun 18.
Abstract
OBJECTIVE
To compare the effects of a eucaloric diet higher in carbohydrate/lower in fat versus lower in carbohydrate/higher in monounsaturated fat on postmeal triglyceride (TG) concentrations and other cardiovascular disease risk factors in nonobese subjects with type 1 diabetes and in good glycemic control.
RESEARCH DESIGN AND METHODS
In a parallel group design study, 30 subjects were randomly assigned and completed one of the two eucaloric diets. Assessments included: BMI, blood pressure, A1C, plasma lipids, and markers of oxidation, thrombosis, and inflammation. At 6 months, subjects were hospitalized for 24 h to measure plasma TG excursions.
RESULTS
There were no significant differences between groups other than decreased plasminogen activator inhibitor 1 (PAI-1) levels and weight gain in the lower-carbohydrate/higher-monounsaturated fat group. During the 24-h testing, the lower-carbohydrate/higher-monounsaturated fat group had a lower plasma TG profile.
CONCLUSIONS
A diet lower in carbohydrate/higher in monounsaturated fat could offer an appropriate choice for nonobese type 1 diabetic individuals with good metabolic and weight control.
摘要
目的
比较碳水化合物含量较高/脂肪含量较低的等热量饮食与碳水化合物含量较低/单不饱和脂肪含量较高的等热量饮食对1型糖尿病且血糖控制良好的非肥胖受试者餐后甘油三酯（TG）浓度及其他心血管疾病风险因素的影响。
研究设计与方法
在一项平行组设计研究中，30名受试者被随机分配并完成两种等热量饮食中的一种。评估内容包括：体重指数、血压、糖化血红蛋白、血脂以及氧化、血栓形成和炎症标志物。6个月时，受试者住院24小时以测量血浆TG波动情况。
结果
除了碳水化合物含量较低/单不饱和脂肪含量较高组的纤溶酶原激活物抑制剂1（PAI-1）水平降低和体重增加外，两组之间无显著差异。在24小时测试期间，碳水化合物含量较低/单不饱和脂肪含量较高组的血浆TG水平较低。
结论
对于代谢和体重控制良好的非肥胖1型糖尿病患者，碳水化合物含量较低/单不饱和脂肪含量较高的饮食可能是一种合适的选择。
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