Anderson P Chris, Dinulos James G
Section of Dermatology, Dartmouth-Hitchcock Medical Center Dartmouth Medical School Lebanon, Lebanon, NH 03756, USA.
Curr Opin Pediatr. 2009 Aug;21(4):486-90. doi: 10.1097/MOP.0b013e32832cfd3b.
The authors discuss the role of moisturizers in the daily skin care regimen of healthy skin and in atopic dermatitis, as well as the efficacy of newer products.
Recent findings have shown that the affected skin of atopic individuals is deficient in ceramides, an integral lipid component of the stratum corneum. Several manufacturers have developed topical products with ceramides in an attempt to replace the missing molecules. These products, though more expensive, have shown moderate efficacy improvements over traditional moisturizers.
Moisturizers are recommended to nearly every atopic patient, and should be part of the daily skin care of these patients, as they have the potential to reduce the quantity of topical steroids necessary to keep disease quiescent. The vast array of choices available to consumers is overwhelming, and most patients would like their physicians to recommend specific products. We attempt to provide a review of the newer products available, with special emphasis on those products that contain ceramides.
作者讨论了保湿剂在健康皮肤和特应性皮炎日常皮肤护理方案中的作用,以及新产品的功效。
最近的研究结果表明,特应性个体的受累皮肤中神经酰胺缺乏,神经酰胺是角质层不可或缺的脂质成分。几家制造商已开发出含神经酰胺的局部用产品,试图替代缺失的分子。这些产品虽更昂贵,但与传统保湿剂相比,已显示出适度的疗效改善。
几乎每位特应性患者都被推荐使用保湿剂,且应成为这些患者日常皮肤护理的一部分,因为它们有可能减少维持病情静止所需的外用类固醇的用量。消费者可选择的产品种类繁多,令人应接不暇,大多数患者希望医生推荐特定产品。我们试图对现有新产品进行综述,特别强调那些含有神经酰胺的产品。