Milani Massimo, Sparavigna Adele
Difa Cooper, Caronno Pertusella, Varese.
Dermatologic Institute Dermig Milan, Milan, Italy.
Clin Cosmet Investig Dermatol. 2017 Aug 11;10:311-315. doi: 10.2147/CCID.S144180. eCollection 2017.
Moisturizing products are commonly used to improve hydration in skin dryness conditions. However, some topical hydrating products could have negative effects on skin barrier function. In addition, hydrating effects of moisturizers are not commonly evaluated up to 24 hours after a single application. Hyaluronic acid (HA) and glycerin are very well-known substances able to improve skin hydration. extract (CAE) could exert lenitive, anti-inflammatory and reepithelialization actions. Furthermore, CAE could inhibit hyaluronidase enzyme activity, therefore prolonging the effect of HA. A fluid containing HA 1%, glycerin 5% and stem cells CAE has been recently developed (Jaluronius CS [JCS] fluid).
To evaluate and compare the 24-hour effects of JCS fluid on skin hydration and on transepidermal water loss (TEWL) in healthy subjects in comparison with the control site.
Twenty healthy women, mean age 40 years, were enrolled in an intra-subject (right vs left), randomized, assessor-blinded, controlled, 1-day trial. The primary end points were the skin hydration and TEWL, evaluated at the volar surface of the forearm and in standardized conditions (temperature- and humidity-controlled room: 23°C and 30% of humidity) using a corneometer and a vapometer device at baseline, 1, 8 and 24 hours after JCS fluid application. Measurements were performed by an operator blinded for the treatments.
Skin hydration after 24 hours was significantly higher (=0.001; Mann-Whitney test) in the JCS-treated area in comparison with the control site. JCS induced a significant (=0.0001) increase in skin hydration at each evaluation time (+59% after 1 hour, +48% after 8 hours and +29% after 24 hours) in comparison with both baseline (=0.0001) and non-treated control site (=0.001). TEWL after 24 hours was significantly lower (=0.049; Mann-Whitney test) in the JCS-treated area in comparison with the control site (13±4 arbitrary units [AU] vs 16±6 AU). JCS fluid significantly reduced post-stripping TEWL in comparison with baseline after 1, 8 and 24 hours (-52%, -32% and -48%, respectively). In the control site, TEWL was not reduced in comparison with baseline values at each time point's evaluation.
A single application of JCS significantly improves skin hydration for up to 24 hours at the same time as improving skin barrier function.
保湿产品常用于改善皮肤干燥状况下的水合作用。然而，一些局部保湿产品可能会对皮肤屏障功能产生负面影响。此外，保湿剂的保湿效果通常在单次使用后24小时内未得到充分评估。透明质酸（HA）和甘油是众所周知的能够改善皮肤水合作用的物质。仙人掌提取物（CAE）可能具有舒缓、抗炎和促进上皮再形成的作用。此外，CAE可以抑制透明质酸酶的活性，从而延长HA的作用效果。最近开发了一种含有1%HA、5%甘油和仙人掌干细胞提取物（CAE）的液体（Jaluronius CS [JCS]液体）。
与对照部位相比，评估和比较JCS液体对健康受试者皮肤水合作用和经表皮水分流失（TEWL）的24小时影响。
20名平均年龄40岁的健康女性参与了一项自身对照（右前臂与左前臂）、随机、评估者盲法、对照的1天试验。主要终点是皮肤水合作用和TEWL，在基线、涂抹JCS液体后1、8和24小时，使用皮肤水分测试仪和水分蒸发仪在前臂掌侧表面以及标准化条件（温度和湿度控制的房间：23°C和湿度为30%）下进行评估。测量由对治疗不知情的操作人员进行。
与对照部位相比，JCS治疗区域24小时后的皮肤水合作用显著更高（P = 0.001；Mann-Whitney检验）。与基线（P = 0.0001）和未治疗的对照部位（P = 0.001）相比，JCS在每个评估时间点均显著（P = 0.0001）增加皮肤水合作用（1小时后增加59%，8小时后增加48%，24小时后增加29%）。与对照部位相比，JCS治疗区域24小时后的TEWL显著更低（P = 0.049；Mann-Whitney检验）（13±4任意单位[AU]对16±6 AU）。与基线相比，JCS液体在1、8和24小时后显著降低了去角质后的TEWL（分别降低52%、32%和48%）。在对照部位，与每个时间点评估的基线值相比，TEWL没有降低。
单次涂抹JCS可在长达24小时内显著改善皮肤水合作用，同时改善皮肤屏障功能。
