γ(c)家族细胞因子对T细胞调控的新见解。
New insights into the regulation of T cells by gamma(c) family cytokines.
作者信息
Rochman Yrina, Spolski Rosanne, Leonard Warren J
机构信息
National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1674, USA.
出版信息
Nat Rev Immunol. 2009 Jul;9(7):480-90. doi: 10.1038/nri2580.
Abstract
Common cytokine receptor gamma-chain (gamma(c)) family cytokines have crucial roles in the development, proliferation, survival and differentiation of multiple cell lineages of both the innate and adaptive immune systems. In this Review, we focus on our current understanding of the distinct and overlapping effects of interleukin-2 (IL-2), IL-7, IL-9, IL-15 and IL-21, as well as the IL-7-related cytokine thymic stromal lymphopoietin (TSLP), on the survival and proliferation of conventional alphabeta T cells, gammadelta T cells and regulatory T cells. This knowledge potentially allows for the therapeutic manipulation of immune responses for the treatment of cancer, autoimmunity, allergic diseases and immunodeficiency, as well as for vaccine development.
摘要
常见细胞因子受体γ链（γ(c)）家族细胞因子在固有免疫系统和适应性免疫系统的多个细胞谱系的发育、增殖、存活及分化过程中发挥着关键作用。在本综述中，我们重点阐述目前对于白细胞介素-2（IL-2）、IL-7、IL-9、IL-15和IL-21，以及与IL-7相关的细胞因子胸腺基质淋巴细胞生成素（TSLP）对传统αβ T细胞、γδ T细胞和调节性T细胞的存活及增殖产生的独特和重叠效应的理解。这些知识有望用于对免疫反应进行治疗性调控，以治疗癌症、自身免疫性疾病、过敏性疾病和免疫缺陷，以及用于疫苗开发。
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