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1例原发性肾上腺弥漫性大B细胞淋巴瘤经利妥昔单抗-CHOP化疗后达到完全缓解。

A case of primary adrenal diffuse large B-cell lymphoma achieving complete remission with rituximab-CHOP chemotherapy.

作者信息

Kim Kyung Min, Yoon Dok Hyun, Lee Seung Geun, Lim Sung Nam, Sug Lyu Jin, Huh Jooryung, Suh Cheolwon

机构信息

Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

出版信息

J Korean Med Sci. 2009 Jun;24(3):525-8. doi: 10.3346/jkms.2009.24.3.525. Epub 2009 Jun 16.

Abstract

Primary adrenal lymphoma is a very rare extranodal lymphoma; its clinical features consist of a high incidence of bilateral adrenal involvement and diffuse large B-cell lymphoma. We report a patient with primary bilateral adrenal diffuse large B-cell lymphoma who achieved complete remission with R-CHOP (rituximab-cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy. A 52-yr-old man presented with fever and progressive fatigue for 3 months. Computed tomography (CT) scans of the abdomen and pelvis demonstrated large bilateral adrenal masses, and a needle biopsy of the left adrenal mass revealed diffuse large B-cell lymphoma. After 6 cycles of R-CHOP chemotherapy, CT scans showed no residual disease. To our knowledge, this is the second report to date of a patient with primary bilateral adrenal diffuse large B-cell lymphoma who achieved complete remission using R-CHOP chemotherapy.

摘要

原发性肾上腺淋巴瘤是一种非常罕见的结外淋巴瘤;其临床特征包括双侧肾上腺受累的高发生率以及弥漫性大B细胞淋巴瘤。我们报告了一例原发性双侧肾上腺弥漫性大B细胞淋巴瘤患者,该患者通过R-CHOP(利妥昔单抗-环磷酰胺、多柔比星、长春新碱和泼尼松)化疗实现了完全缓解。一名52岁男性出现发热和进行性疲劳3个月。腹部和骨盆的计算机断层扫描(CT)显示双侧肾上腺有巨大肿块,左肾上腺肿块的穿刺活检显示为弥漫性大B细胞淋巴瘤。经过6个周期的R-CHOP化疗后,CT扫描显示无残留病灶。据我们所知,这是迄今为止第二例使用R-CHOP化疗实现完全缓解的原发性双侧肾上腺弥漫性大B细胞淋巴瘤患者的报告。

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