Wise Jasen L, Crout Richard J, McNeil Daniel W, Weyant Robert J, Marazita Mary L, Wenger Sharon L
Department of Pathology, West Virginia University, Morgantown, WV, USA.
PLoS One. 2009 Jun 23;4(6):e6013. doi: 10.1371/journal.pone.0006013.
The majority of human telomere length studies have focused on the overall length of telomeres within a cell. In fact, very few studies have examined telomere length for individual chromosome arms. The objective of this study was to examine the relationship between chromosome arm size and the relative length of the associated telomere. Quantitative Fluorescence In Situ Hybridization (Q-FISH) was used to measure the relative telomere length of each chromosome arm in metaphases from cultured lymphocytes of 17 individuals. A statistically significant positive correlation (r = 0.6) was found between telomere length and the size of the associated chromosome arm, which was estimated based on megabase pair measurements from (http://www.ncbi.nlm.nih.gov/projects/mapview/).
大多数人类端粒长度研究都集中在细胞内端粒的整体长度上。事实上，很少有研究检测单个染色体臂的端粒长度。本研究的目的是检验染色体臂大小与相关端粒相对长度之间的关系。采用定量荧光原位杂交（Q-FISH）技术测量了17名个体培养淋巴细胞中期各染色体臂的相对端粒长度。基于（http://www.ncbi.nlm.nih.gov/projects/mapview/）的兆碱基对测量值估计，发现端粒长度与相关染色体臂大小之间存在统计学上显著的正相关（r = 0.6）。
