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6岁以下儿童的去骨瓣减压术:重度颅脑创伤的死亡率预测因素

Defenestration in children younger than 6 years old: mortality predictors in severe head trauma.

作者信息

Melo Jose Roberto Tude, Di Rocco Federico, Lemos-Júnior Laudenor Pereira, Roujeau Thomas, Thélot Bertrand, Sainte-Rose Christian, Meyer Philippe, Zerah Michel

机构信息

Department of Pediatric Neurosurgery Hôpital Necker-Enfants Malades (Assistance Publique Hôpitaux de Paris-France), Université Descartes Paris 5, Paris, France.

出版信息

Childs Nerv Syst. 2009 Sep;25(9):1077-83. doi: 10.1007/s00381-009-0924-5. Epub 2009 Jun 24.

Abstract

PURPOSE

This study aims to describe the characteristics of severe head injuries in children less than 6 years old, victims of falls from windows, and identify the main predictive factors of mortality in this population.

PATIENTS AND METHODS

A cross-sectional study was designed through data derived from medical records of less than 6-year-old children victims of falls from windows presenting with a severe head injury defined by an initial Glasgow coma scale (GCS) < or =8, hospitalized at a Pediatric Trauma center level III, between January 2000 and December 2005. Statistical analysis used univariate analysis and multiple logistic regressions.

RESULTS

We identified 58 severe head injuries in children victims of falls from windows. The mean age was 2.8 +/- 1.4 years, with a male prevalence (64%); 48% of patients had a GCS < or =5; 62.1% had a Pediatric Trauma Score (PTS) < or =3 at hospital admission. The mortality rate was 41% (24/58) and most of them (88%; 21/24) died within 48 h. An increased death rate was noted in children admitted with hypoxemia (p = 0.001), low systolic blood pressure (p = 0.002), hypothermia (p = 0.0001), GCS < or =5 (p = 10(-5)), PTS < or =3 (p = 0.008), hyperglycemia (p = 0.023), coagulation disorders (p = 0.02), and initial intracranial pressure > or =20 mmHg (p = 0.03). Initial hypothermia, hyperglycemia, and coagulation disorders were the only independent predictive factors of mortality.

CONCLUSION

Severe head injuries resulting from falls from windows carry a high risk of mortality in less than 6-year-old children. Hypothermia, hyperglycemia, and coagulation's disorders are independent predictive factors of mortality. Early deaths could be considered as direct consequences of uncontrollable brain lesions.

摘要

目的

本研究旨在描述6岁以下儿童因从窗户坠落导致严重头部损伤的特征,并确定该人群中死亡的主要预测因素。

患者与方法

通过收集2000年1月至2005年12月期间在三级儿科创伤中心住院的6岁以下因从窗户坠落导致严重头部损伤(初始格拉斯哥昏迷量表(GCS)≤8)儿童的病历数据,设计了一项横断面研究。统计分析采用单因素分析和多因素逻辑回归。

结果

我们确定了58例因从窗户坠落导致严重头部损伤的儿童。平均年龄为2.8±1.4岁,男性占比(64%);其中48%的患者GCS≤5;62.1%的患者入院时儿科创伤评分(PTS)≤3。死亡率为41%(24/58)且大多数(88%;21/24)在48小时内死亡。发现伴有低氧血症(p = 0.001)、收缩压降低(p = 0.002)、体温过低(p = 0. /0001)、GCS≤5(p = 10⁻⁵)、PTS≤3(p = 0.008)、高血糖(p = 0.023)、凝血障碍(p = 0.02)以及初始颅内压≥20 mmHg(p = 0.03)的儿童死亡率增加。初始体温过低、高血糖和凝血障碍是死亡的唯一独立预测因素。

结论

6岁以下儿童因从窗户坠落导致的严重头部损伤具有很高的死亡风险。体温过低、高血糖和凝血障碍是死亡的独立预测因素。早期死亡可被视为无法控制的脑损伤的直接后果。

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