具有促进胃肠蠕动及抑制胰脂肪酶作用的酰化齐墩果烷型三萜皂苷——来自茶树（Camellia sinensis）花芽

Acylated oleanane-type triterpene saponins with acceleration of gastrointestinal transit and inhibitory effect on pancreatic lipase from flower buds of chinese tea plant (Camellia sinensis).

作者信息

Yoshikawa Masayuki, Sugimoto Sachiko, Kato Yasuyo, Nakamura Seikou, Wang Tao, Yamashita Chihiro, Matsuda Hisashi

机构信息

Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan.

出版信息

Chem Biodivers. 2009 Jun;6(6):903-15. doi: 10.1002/cbdv.200800153.

DOI:10.1002/cbdv.200800153

PMID:19551732

Abstract

The MeOH extract and its BuOH-soluble fraction (crude saponin fraction) from the flower buds of Chinese tea plant (Camellia sinensis (L.) O. KUNTZE; Fujian Province) were found to exhibit accelerating effects on gastrointestinal transit in mice and inhibitory effects against pancreatic lipase. From the BuOH-soluble fraction, three new acylated oleanane-type triterpene oligoglycosides, chakasaponins I, II, and III (1-3, resp.), were isolated together with 13 known compounds. The chemical structures 1-3 were elucidated on the basis of chemical and physicochemical evidence. Compounds 1-3 showed accelerating effects on gastrointestinal transit in mice and inhibitory effects against porcine pancreatic lipase (IC(50)=150-530 microM).

摘要

从中国茶树（Camellia sinensis (L.) O. KUNTZE；福建省）花蕾中提取的甲醇提取物及其正丁醇可溶部分（粗皂苷部分）对小鼠胃肠蠕动有促进作用，对胰脂肪酶有抑制作用。从正丁醇可溶部分中分离出三种新的酰化齐墩果烷型三萜寡糖苷，茶卡皂苷I、II和III（分别为1-3）以及13种已知化合物。根据化学和物理化学证据阐明了化合物1-3的化学结构。化合物1-3对小鼠胃肠蠕动有促进作用，对猪胰脂肪酶有抑制作用（IC(50)=150-530 microM）。