Matsuda Hisashi, Nakamura Seikou, Fujimoto Katsuyoshi, Moriuchi Ryo, Kimura Yuta, Ikoma Noriko, Hata Yuki, Muraoka Osamu, Yoshikawa Masayuki
Kyoto Pharmaceutical University, Kyoto, Japan.
Chem Pharm Bull (Tokyo). 2010 Dec;58(12):1617-21. doi: 10.1248/cpb.58.1617.
The methanolic extract and its 1-butanol-soluble fraction from the flower buds of Camellia sasanqua THUNB. were found to show inhibitory activities on the release of β-hexosaminidase from rat basophile leukemia (RBL-2H3) cells. From the 1-butanol-soluble fraction, five new acylated oleanane-type triterpene saponins, sasanquasaponins I-V, were isolated together with a known saponin and their chemical structures were elucidated on the basis of chemical and physicochemical evidence. The principal saponin constituents, sasanquasaponins I-III, with an acyl group at the 22-position of the aglycon part showed the inhibitory effects on the release of β-hexosaminidase and some structure-activity relationships were reported.
从茶梅（Camellia sasanqua THUNB.）花蕾中得到的甲醇提取物及其正丁醇可溶部分，对大鼠嗜碱性粒细胞白血病（RBL-2H3）细胞释放β-己糖胺酶显示出抑制活性。从正丁醇可溶部分分离得到了5个新的酰化齐墩果烷型三萜皂苷——茶梅皂苷I-V以及1个已知皂苷，并根据化学和物理化学证据阐明了它们的化学结构。苷元部分22位带有酰基的主要皂苷成分茶梅皂苷I-III对β-己糖胺酶的释放具有抑制作用，并报道了一些构效关系。
