Lazebnik L B, Drozdov V N, Kim V A
Eksp Klin Gastroenterol. 2009(2):3-9.
This article presents results of the first Russian randomized study of NSAID-gastropaty prevention at patients receiving NSAIDS. Results of clinical and endoscopic monitoring of two groups of patients: 1st - 108 patients with AA or RA treated with diclofenac and famotidin and 2nd--116 patients with AA or RA receiving diclofenac treatment only. It was shown that combined use of diclofenac and famotidin reduces to 2.6 times frequency and significantly reduces severity of painful dyspepsia symptoms and antipain manifestations reduces more than twice frequency of erosive-ulcerous lesions of gastric mucosa and duodenum.
本文介绍了俄罗斯首例针对接受非甾体抗炎药（NSAIDs）治疗患者的NSAIDs相关性胃病预防随机研究结果。对两组患者进行了临床和内镜监测：第一组为108例患有强直性脊柱炎（AA）或类风湿关节炎（RA）且接受双氯芬酸和法莫替丁治疗的患者，第二组为116例患有AA或RA且仅接受双氯芬酸治疗的患者。结果表明，双氯芬酸与法莫替丁联合使用可使疼痛性消化不良症状的发生频率降低2.6倍，并显著减轻其严重程度，抗疼痛表现使胃黏膜和十二指肠糜烂性溃疡病变的发生频率降低超过两倍。
