Factor-Litvak P, Graziano J H, Kline J K, Popovac D, Mehmeti A, Ahmedi G, Shrout P, Murphy M J, Gashi E, Haxhiu R
Division of Epidemiology, Columbia University, New York, NY 10032.
Int J Epidemiol. 1991 Sep;20(3):722-8. doi: 10.1093/ije/20.3.722.
This paper tests the hypothesis that exposure to lead during pregnancy is associated with reduced intrauterine growth and an increase in preterm delivery. The sample comprises women, recruited at mid-pregnancy, residing in Titova Mitrovica, a lead smelter town, or in Pristina, a non-exposed town 25 miles away. Both towns are in the province of Kosovo, Yugoslavia. Mean blood lead concentrations (BPb's) at mid-pregnancy were 0.92 mumol/L (+/- 0.38, N = 401) in the exposed town and 0.27 mumol/L (+/- 0.09, N = 506) in the comparison town. No differences were found between towns for either birthweight or length of gestation. Mean birthweight was 3308 (+/- 566) grams in Titova Mitrovica and 3361 (+/- 525) grams in Pristina. Mean length of gestation was 274 (+/- 18.8) days in Titova Mitrovica and 275 (+/- 15.6) days in Pristina. After adjustment for the effects of potential confounders, no significant relationships were found between maternal BPb measured at mid-pregnancy, at delivery or in the umbilical cord and either birthweight, length of gestation, or preterm delivery (less than 37 weeks). We conclude that exposure to environmental lead does not impair fetal growth or influence length of gestation.
孕期接触铅与子宫内生长减缓及早产增加有关。样本包括在妊娠中期招募的女性，她们居住在铅冶炼城镇蒂托瓦米特罗维察，或距离其25英里外未受铅污染的城镇普里什蒂纳。这两个城镇都位于南斯拉夫科索沃省。妊娠中期，暴露城镇的平均血铅浓度（BPb）为0.92微摩尔/升（±0.38，N = 401），对照城镇为0.27微摩尔/升（±0.09，N = 506）。在出生体重或妊娠期长度方面，两个城镇之间未发现差异。蒂托瓦米特罗维察的平均出生体重为3308（±566）克，普里什蒂纳为3361（±525）克。蒂托瓦米特罗维察的平均妊娠期长度为274（±18.8）天，普里什蒂纳为275（±15.6）天。在对潜在混杂因素的影响进行调整后，未发现妊娠中期、分娩时或脐带血中测得的母亲血铅浓度与出生体重、妊娠期长度或早产（小于37周）之间存在显著关系。我们得出结论，接触环境铅不会损害胎儿生长或影响妊娠期长度。
