Loiacono N J, Graziano J H, Kline J K, Popovac D, Ahmedi X, Gashi E, Mehmeti A, Rajovic B
Department of Pharmacology, Columbia University, New York, New York.
Arch Environ Health. 1992 Jul-Aug;47(4):250-5. doi: 10.1080/00039896.1992.9938357.
It has been suggested that the accumulation of tobacco-derived cadmium (Cd) in the placenta is responsible for the adverse effect of cigarette smoking on infant birthweight. We chose to test this hypothesis; therefore, we studied a population of nonsmoking pregnant women who were exposed to low levels of smelter-derived Cd and a group of nonexposed women. A higher mean placental Cd concentration (p less than .0007) was found in the exposed women (n = 106), compared with those who were not exposed (n = 55); the observed Cd concentrations were comparable to concentrations reported previously for smoking and nonsmoking women, respectively. Least squares multiple regression (controlling for potentially confounding variables) revealed no association between placental Cd and birthweight. It was, therefore, concluded that the effect of smoking on birthweight was not mediated through Cd.
有人提出，胎盘内烟草衍生镉（Cd）的积累是吸烟对婴儿出生体重产生不利影响的原因。我们选择对这一假设进行检验；因此，我们研究了一群接触低水平冶炼厂衍生镉的非吸烟孕妇以及一组未接触镉的女性。与未接触镉的女性（n = 55）相比，接触镉的女性（n = 106）胎盘镉平均浓度更高（p < 0.0007）；观察到的镉浓度分别与之前报道的吸烟和非吸烟女性的浓度相当。最小二乘多元回归（控制潜在混杂变量）显示胎盘镉与出生体重之间没有关联。因此，得出的结论是，吸烟对出生体重的影响不是通过镉介导的。
