Streilein J W, Wiesner J
J Exp Med. 1977 Sep 1;146(3):809-16. doi: 10.1084/jem.146.3.809.
The tempo with which C57BL/6 females reject male skin isografts is determined in part by the immunogenicity of the H-Y antigen and in part by the capacity of the host to respond immunologically. Our studies indicate that the spleen plays an important role in determining the briskness of the rejection process in that splenectomy 7-30 days before grafting with male skin significantly shortens the survival time. The results of reconstitution experiments suggests that a population of cells is present in spleens of normal, but not specifically sensitized, females which can restore the conventional first set reaction in splenectomized females. It is inferred that this resident population normally operates in spleen-intact females to delay the development of specific effector responses. Lymphoid cells from H-Y antigen-sensitized, splenectomized females failed to evoke graft-vs.-host responses in males whereas similar cells from females with spleens intact did possess graft-vs.-host potential.
C57BL/6雌性小鼠排斥雄性皮肤同基因移植的速度，部分取决于H-Y抗原的免疫原性，部分取决于宿主的免疫反应能力。我们的研究表明，脾脏在决定排斥过程的迅速程度方面起着重要作用，因为在移植雄性皮肤前7至30天进行脾切除术会显著缩短存活时间。重建实验结果表明，正常但未经过特异性致敏的雌性小鼠脾脏中存在一群细胞，它们能够恢复脾切除雌性小鼠的传统初次免疫反应。据推测，这群常驻细胞通常在脾脏完整的雌性小鼠中发挥作用，以延迟特异性效应反应的发展。来自H-Y抗原致敏的脾切除雌性小鼠的淋巴细胞未能在雄性小鼠中引发移植物抗宿主反应，而来自脾脏完整的雌性小鼠的类似细胞则具有移植物抗宿主潜力。
