Faculty of Health Sciences, Ben Gurion University of the Negev, Be'er-Sheva, Israel.
Arch Gynecol Obstet. 2010 May;281(5):811-5. doi: 10.1007/s00404-009-1158-1. Epub 2009 Jun 25.
To investigate pregnancy outcome of patients with dermoid and other benign ovarian cysts.
A population-based study comparing all pregnancies of women with and without benign ovarian cysts was conducted. Deliveries occurred during the years 1988-2007 at Soroka University Medical Center. A multivariate logistic regression model, with backward elimination, was constructed to find independent risk factors associated with benign ovarian cysts.
During the study period there were 212,114 deliveries, of which 93 occurred in patients with benign ovarian cysts. Most of the lesions were benign cyatadenoma (41.9%), 36.7% were dermoid cyst, and 11.8% were adenofibroma, mostly diagnosed during cesarean delivery (76.3%). Others (12.9%) were diagnosed during pregnancy by ultrasonography and the remaining 10.8% were diagnosed before pregnancy. The mean diameter at diagnosis was 9.05+/-7.6 cm for cystadenoma, 6.09+/-3.0 cm for dermoid cyst and 4.55+/-4.1 cm for adenofibroma. Only 3 cases of ovarian torsion were noted (3.2%), and 15 cases of hospitalization due to abdominal pain (16.2%). The following conditions were significantly associated with benign ovarian cysts: hypertensive disorder [odds ratio (OR) 3.05; 95% confidence interval (CI) 1.87-4.97], and maternal age (OR 1.04; 95% CI 1.01-1.07). Ovarian dermoid cyst was significantly associated with fertility treatments (8.6 vs. 2.4% OR=3.75; 95% CI 1.1-12.2; P=0.019). In addition, after controlling for maternal age using a multivariate analysis, fertility treatments remained significantly associated with ovarian dermoid. No significant differences were noted between the groups regarding perinatal outcomes such as birth weight, low birth weight, congenital malformations, low Apgar scores, or perinatal mortality.
The course of pregnancy of patients with dermoid and other benign ovarian cysts, including perinatal outcomes, is favorable. The cysts should be managed conservatively if possible with routine ultrasound follow up during the pregnancy since complications are extremely rare.
探讨皮样囊肿和其他良性卵巢囊肿患者的妊娠结局。
本研究为基于人群的研究，比较了所有患有良性卵巢囊肿和无良性卵巢囊肿的妇女的妊娠情况。这些分娩均发生在 1988 年至 2007 年期间的索罗卡大学医学中心。采用逐步后退的多变量逻辑回归模型来确定与良性卵巢囊肿相关的独立危险因素。
在研究期间，共有 212114 例分娩，其中 93 例发生在患有良性卵巢囊肿的患者中。大多数病变为良性囊腺瘤（41.9％），36.7％为皮样囊肿，11.8％为腺纤维瘤，其中大多数（76.3％）是在剖宫产时诊断的。其他（12.9％）在怀孕期间通过超声诊断，其余 10.8％在怀孕前诊断。诊断时的平均直径为囊腺瘤 9.05±7.6cm，皮样囊肿 6.09±3.0cm，腺纤维瘤 4.55±4.1cm。仅注意到 3 例卵巢扭转（3.2％）和 15 例因腹痛住院（16.2％）。以下情况与良性卵巢囊肿明显相关：高血压疾病（OR 3.05；95％CI 1.87-4.97）和产妇年龄（OR 1.04；95％CI 1.01-1.07）。卵巢皮样囊肿与生育治疗明显相关（8.6％比 2.4％OR=3.75；95％CI 1.1-12.2；P=0.019）。在用多变量分析控制产妇年龄后，生育治疗与卵巢皮样囊肿仍明显相关。两组在围产儿结局（如出生体重，低出生体重，先天性畸形，低 Apgar 评分或围产期死亡率）方面无显着差异。
皮样囊肿和其他良性卵巢囊肿患者的妊娠过程，包括围产儿结局，均是有利的。如果可能的话，应通过常规超声检查在怀孕期间对囊肿进行保守治疗，因为并发症极为罕见。
