Sheng Yaru, Yuan Jiangjing, Wang Jing, Wang Liya, Li Yuhong, Wang Yudong
Department of Gynecologic Oncology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, People's Republic of China.
Int J Womens Health. 2022 Oct 17;14:1477-1487. doi: 10.2147/IJWH.S381297. eCollection 2022.
Ovarian mature cystic teratomas (MCTs) are the most common tumors in pregnant women. The premature rupture of membranes (PROM) is a typical complication of pregnancy; however, the relationship between MCT and PROM is unknown. Therefore, we aimed to determine whether MCT is associated with the occurrence of PROM during pregnancy.
The data of patients with adnexal masses during pregnancy between January 2017 and August 2021 were retrospectively analyzed. Ovarian cystectomy was performed during cesarean delivery or after vaginal delivery. Univariate and multivariate logistic regression models were used for statistical analysis.
A total of 234 patients with histopathological results were included. Among these patients, 21 occurred PROM during pregnancy, of which 11 were diagnosed with MCT. Compared with other subtypes, MCT (p=0.025) showed a stronger correlation with PROM and was an independent risk factor for PROM (odds ratio [OR], 2.811; 95% confidence interval [CI], 1.096-7.215; p=0.032). Furthermore, we found that MCT with a diameter >5 cm (p=0.0037) was more likely to promote the development of PROM than those that with a diameter <5 cm.
MCT was an independent risk factor for PROM during pregnancy. Positive actions and preventative clinical treatments should be fully taken into consideration by clinicians for pregnant women with MCTs, especially those ≥5 cm in diameter, to reduce the clinical complications related to MCT-associated PROM.
卵巢成熟囊性畸胎瘤（MCT）是孕妇中最常见的肿瘤。胎膜早破（PROM）是妊娠的典型并发症；然而，MCT与PROM之间的关系尚不清楚。因此，我们旨在确定MCT是否与妊娠期PROM的发生有关。
回顾性分析2017年1月至2021年8月期间妊娠合并附件包块患者的数据。在剖宫产或阴道分娩后行卵巢囊肿切除术。采用单因素和多因素逻辑回归模型进行统计分析。
共纳入234例有组织病理学结果的患者。在这些患者中，21例在孕期发生了PROM，其中11例被诊断为MCT。与其他亚型相比，MCT（p=0.025）与PROM的相关性更强，是PROM的独立危险因素（比值比[OR]，2.811；95%置信区间[CI]，1.096-7.215；p=0.032）。此外，我们发现直径>5 cm的MCT（p=0.0037）比直径<5 cm的MCT更易促进PROM的发生。
MCT是妊娠期PROM的独立危险因素。临床医生应充分考虑对患有MCT的孕妇，尤其是直径≥5 cm的孕妇采取积极措施和预防性临床治疗，以减少与MCT相关的PROM的临床并发症。
