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An additional spirocyclization for duocarmycin SA.
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Total synthesis and evaluation of iso-duocarmycin SA and iso-yatakemycin.
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Synthesis and evaluation of a thio analogue of duocarmycin SA.
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Establishment of substituent effects in the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065.
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Duocarmycins, new antitumor antibiotics produced by Streptomyces; producing organisms and improved production.
J Antibiot (Tokyo). 1991 Oct;44(10):1045-53. doi: 10.7164/antibiotics.44.1045.
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Duocarmycins binding to DNA investigated by molecular simulation.
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DNA alkylation properties of yatakemycin.
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2
The Difference a Single Atom Can Make: Synthesis and Design at the Chemistry-Biology Interface.
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Natural products: Beyond grind and find.
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Synthesis and evaluation of a series of C5'-substituted duocarmycin SA analogs.
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Synthesis and evaluation of a thio analogue of duocarmycin SA.
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10
Total synthesis and evaluation of iso-duocarmycin SA and iso-yatakemycin.
J Am Chem Soc. 2009 Jan 28;131(3):1187-94. doi: 10.1021/ja808108q.

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1
Rational design, synthesis, and evaluation of key analogues of CC-1065 and the duocarmycins.
J Am Chem Soc. 2007 Nov 14;129(45):14092-9. doi: 10.1021/ja073989z. Epub 2007 Oct 19.
3
Solution kinetics of CC-1065 A-ring opening: substituent effects and general acid/base catalysis.
J Am Chem Soc. 2006 Mar 22;128(11):3722-7. doi: 10.1021/ja057289a.
4
Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin.
Nat Chem Biol. 2006 Feb;2(2):79-82. doi: 10.1038/nchembio761. Epub 2006 Jan 15.
5
Total synthesis, structure revision, and absolute configuration of (+)-yatakemycin.
J Am Chem Soc. 2004 Jul 14;126(27):8396-8. doi: 10.1021/ja0472735.
7
DNA alkylation properties of yatakemycin.
J Am Chem Soc. 2003 Sep 10;125(36):10971-6. doi: 10.1021/ja035984h.
8
Yatakemycin, a novel antifungal antibiotic produced by Streptomyces sp. TP-A0356.
J Antibiot (Tokyo). 2003 Feb;56(2):107-13. doi: 10.7164/antibiotics.56.107.
9
The DNA phosphate backbone is not involved in catalysis of the duocarmycin and CC-1065 DNA alkylation reaction.
Bioorg Med Chem Lett. 2002 Feb 11;12(3):303-6. doi: 10.1016/s0960-894x(01)00740-5.
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Synthesis and antitumor activity of duocarmycin derivatives: A-ring pyrrole analogues of duocarmycin B2.
Bioorg Med Chem. 1996 Aug;4(8):1379-91. doi: 10.1016/0968-0896(96)00132-0.

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