Fundamental relationships between structure, reactivity, and biological activity for the duocarmycins and CC-1065.
作者信息
MacMillan Karen S, Boger Dale L
机构信息
Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA.
出版信息
J Med Chem. 2009 Oct 8;52(19):5771-80. doi: 10.1021/jm9006214.
Abstract
摘要
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An additional spirocyclization for duocarmycin SA.多卡霉素SA的额外螺环化反应。
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Total synthesis and evaluation of iso-duocarmycin SA and iso-yatakemycin.异多卡霉素SA和异矢车菊霉素的全合成及评估
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Rational design, synthesis, and evaluation of key analogues of CC-1065 and the duocarmycins.CC-1065和双环霉素关键类似物的合理设计、合成与评估
J Am Chem Soc. 2007 Nov 14;129(45):14092-9. doi: 10.1021/ja073989z. Epub 2007 Oct 19.
7
Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity.对影响DNA烷基化和生物活性的谷田霉素结构特征的系统探索。
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8
Asymmetric total synthesis of (+)- and ent-(-)-yatakemycin and duocarmycin SA: evaluation of yatakemycin key partial structures and its unnatural enantiomer.（+）-和对映体-（-）-Yatakemycin及多卡霉素SA的不对称全合成：Yatakemycin关键部分结构及其非天然对映体的评估
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