Gauss Carla M, Hamasaki Akiyuki, Parrish Jay P, Macmillan Karen S, Rayl Thomas J, Hwang Inkyu, Boger Dale L
Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Tetrahedron. 2009 Aug 15;65(33):6591-6599. doi: 10.1016/j.tet.2009.02.065.
Efficient syntheses and a preliminary evaluation of 1,2,11,11a-tetrahydrocyclopropa[c]-naphtho[2,3-e]indole (CNI) and 1,2,11,11a-tetrahydrocyclopropa[c]naphtho[1,2-e]indole (iso-CNI), and their derivatives containing an anthracene and phenanthrene variant of the CC-1065 or duocarmycin alkylation subunit are detailed.
详细介绍了1,2,11,11a-四氢环丙[c]-萘并[2,3-e]吲哚(CNI)和1,2,11,11a-四氢环丙[c]萘并[1,2-e]吲哚(异-CNI)及其含有CC-1065或双吲哚霉素烷基化亚基的蒽和菲变体的衍生物的高效合成及初步评估。