Suguikawa Thais R, Garcia Clecia A, Martinez Edson Z, Vianna Elcio O
Department of Medicine, Medical School of Ribeirão Preto, University of S, Paulo at Ribeirão Preto, Brazil.
Cough. 2009 Jun 25;5:6. doi: 10.1186/1745-9974-5-6.
Bronchial challenge tests are used to evaluate bronchial responsiveness in diagnosis and follow-up of asthmatic patients. Challenge induced cough has increasingly been recognized as a valuable diagnostic tool. Various stimuli and protocols have been employed. The aim of this study was to compare cough and dyspnea intensity induced by different stimuli.
Twenty asthmatic patients underwent challenge tests with methacholine, bradykinin and exercise. Cough was counted during challenge tests. Dyspnea was assessed by modified Borg scale and visual analogue scale. Statistical comparisons were performed by linear mixed-effects model.
For cough evaluation, bradykinin was the most potent trigger (p < 0.01). In terms of dyspnea measured by Borg scale, there were no differences among stimuli (p > 0.05). By visual analogue scale, bradykinin induced more dyspnea than other stimuli (p < or = 0.04).
Bradykinin seems to be the most suitable stimulus for bronchial challenge tests intended for measuring cough in association with bronchoconstriction.
支气管激发试验用于评估哮喘患者诊断及随访中的支气管反应性。激发诱导咳嗽日益被视为一种有价值的诊断工具。已采用了各种刺激物和方案。本研究的目的是比较不同刺激物诱发的咳嗽和呼吸困难强度。
20名哮喘患者接受了乙酰甲胆碱、缓激肽和运动激发试验。在激发试验期间计数咳嗽次数。通过改良的博格量表和视觉模拟量表评估呼吸困难情况。采用线性混合效应模型进行统计学比较。
对于咳嗽评估，缓激肽是最有效的触发因素（p < 0.01）。就通过博格量表测量的呼吸困难而言，各刺激物之间无差异（p > 0.05）。通过视觉模拟量表，缓激肽诱发的呼吸困难比其他刺激物更严重（p ≤ 0.04）。
缓激肽似乎是用于测量与支气管收缩相关咳嗽的支气管激发试验的最合适刺激物。
