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与母亲年龄相关的学龄前儿童免疫接种覆盖率差异。

Disparities in preschool immunization coverage associated with maternal age.

作者信息

Salmon Daniel A, Smith Philip J, Pan William K Y, Navar Ann Marie, Omer Saad B, Halsey Neal A

机构信息

Institute for Vaccine Safety and Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

出版信息

Hum Vaccin. 2009 Aug;5(8):557-61. doi: 10.4161/hv.5.8.9009. Epub 2009 Aug 14.

Abstract

Associations between maternal age and preschool immunization coverage are unclear. This study aimed to determine if maternal age is associated with preschool immunization coverage and the importance of maternal age compared with other factors affecting vaccination coverage. Data from the 2001-2003 National Immunization Survey (NIS) were used to estimate vaccine coverage. Children were considered up-to-date (UTD) if they received > or =4 doses of DTaP, > or =3 doses of polio, > or =1 doses of MMR, > or =3 doses of Hib and > or =3 doses of Hep B. Bivariate and multivariate relationships between UTD coverage and maternal, child and household factors were evaluated. Classification tree analysis assessed complex interactions between maternal, child and household factors associated with UTD coverage and isolated the most important factors in predicting UTD coverage. UTD coverage was significantly associated with maternal age: coverage increased as maternal age increased. Coverage among children with 17 year old mothers was 64%; coverage among children of mothers 17-26 years old increased by 16.3% overall (approximately 1.8% per year). After 26 years of age, coverage did not increase significantly as maternal age increased. The relationship between maternal age and UTD coverage remained statistically significant after adjusting for a broad range of maternal, child and household factors. Classification tree analysis suggested that maternal age is the most important factor associated with vaccine coverage. More research is needed to determine the reasons for underimmunization of children born to young mothers.

摘要

母亲年龄与学龄前儿童免疫接种覆盖率之间的关联尚不清楚。本研究旨在确定母亲年龄是否与学龄前儿童免疫接种覆盖率相关,以及与影响疫苗接种覆盖率的其他因素相比,母亲年龄的重要性。利用2001 - 2003年国家免疫调查(NIS)的数据来估计疫苗接种覆盖率。如果儿童接种了≥4剂白百破疫苗、≥3剂脊髓灰质炎疫苗、≥1剂麻疹腮腺炎风疹疫苗、≥3剂b型流感嗜血杆菌疫苗和≥3剂乙肝疫苗,则被视为疫苗接种及时(UTD)。评估了UTD覆盖率与母亲、儿童和家庭因素之间的双变量和多变量关系。分类树分析评估了与UTD覆盖率相关的母亲、儿童和家庭因素之间的复杂相互作用,并找出了预测UTD覆盖率的最重要因素。UTD覆盖率与母亲年龄显著相关:随着母亲年龄的增加,覆盖率也增加。母亲年龄为17岁的儿童的覆盖率为64%;母亲年龄在17 - 26岁之间的儿童的覆盖率总体增加了16.3%(每年约1.8%)。26岁之后,随着母亲年龄的增加,覆盖率没有显著增加。在对一系列广泛的母亲、儿童和家庭因素进行调整后,母亲年龄与UTD覆盖率之间的关系在统计学上仍然显著。分类树分析表明,母亲年龄是与疫苗接种覆盖率相关的最重要因素。需要更多的研究来确定年轻母亲所生孩子免疫接种不足的原因。

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