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发育生物学中的波与模式形成:以脊椎动物体节形成和羽芽形成为例的研究

Waves and patterning in developmental biology: vertebrate segmentation and feather bud formation as case studies.

作者信息

Baker Ruth E, Schnell Santiago, Maini Philip K

机构信息

Centre for Mathematical Biology, University of Oxford, UK.

出版信息

Int J Dev Biol. 2009;53(5-6):783-94. doi: 10.1387/ijdb.072493rb.

Abstract

In this article we will discuss the integration of developmental patterning mechanisms with waves of competency that control the ability of a homogeneous field of cells to react to pattern forming cues and generate spatially heterogeneous patterns. We base our discussion around two well known patterning events that take place in the early embryo: somitogenesis and feather bud formation. We outline mathematical models to describe each patterning mechanism, present the results of numerical simulations and discuss the validity of each model in relation to our example patterning processes.

摘要

在本文中,我们将讨论发育模式形成机制与能力波的整合,这些能力波控制着均匀细胞场对模式形成线索做出反应并产生空间异质模式的能力。我们围绕早期胚胎中发生的两个著名的模式形成事件展开讨论:体节发生和羽毛芽形成。我们概述了描述每种模式形成机制的数学模型,展示了数值模拟的结果,并讨论了每个模型相对于我们的示例模式形成过程的有效性。

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