Department of Neurobiology, Physiology, and Behavior, University of California, Davis, CA 95616, USA.
Curr Opin Cell Biol. 2013 Feb;25(1):107-15. doi: 10.1016/j.ceb.2012.08.012. Epub 2012 Sep 15.
Much of current understanding of cell motility arose from studying steady treadmilling of actin arrays. Recently, there have been a growing number of observations of a more complex, non-steady, actin behavior, including self-organized waves. It is becoming clear that these waves result from activation and inhibition feedbacks in actin dynamics acting on different scales, but the exact molecular nature of these feedbacks and the respective roles of biomechanics and biochemistry are still unclear. Here, we review recent advances achieved in experimental and theoretical studies of actin waves and discuss mechanisms and physiological significance of wavy protrusions.
目前对细胞运动的理解在很大程度上源于对肌动蛋白阵列稳定的履带式运动的研究。最近，越来越多的观察到更复杂的、非稳态的肌动蛋白行为，包括自组织波。现在已经很清楚，这些波是由肌动蛋白动力学中的激活和抑制反馈作用于不同尺度而产生的，但这些反馈的确切分子性质以及生物力学和生物化学的各自作用仍不清楚。在这里，我们回顾了在肌动蛋白波的实验和理论研究中取得的最新进展，并讨论了波状突起的机制和生理意义。
