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Cytochrome P450 enzymes as human autoantigens.

作者信息

Manns M P

机构信息

I. Medizinische Klinik und Poliklinik, Johannes-Gutenberg-Universität, Mainz, BRD.

出版信息

Immunol Res. 1991;10(3-4):503-7. doi: 10.1007/BF02919749.

DOI:10.1007/BF02919749
PMID:1955778
Abstract
摘要

相似文献

1
Cytochrome P450 enzymes as human autoantigens.细胞色素P450酶作为人类自身抗原。
Immunol Res. 1991;10(3-4):503-7. doi: 10.1007/BF02919749.
2
Immunoreactivity to various human cytochrome P450 proteins of sera from patients with autoimmune hepatitis, chronic hepatitis B, and chronic hepatitis C.自身免疫性肝炎、慢性乙型肝炎和慢性丙型肝炎患者血清对各种人类细胞色素P450蛋白的免疫反应性。
Autoimmunity. 2000;33(1):23-32. doi: 10.3109/08916930108994106.
3
And the beat goes on: discovery of "new" autoantigens.
Gastroenterology. 1998 Feb;114(2):400-3. doi: 10.1016/s0016-5085(98)70493-7.
4
Drug-metabolizing enzymes and therapeutic drug monitoring in psychiatry.精神科中的药物代谢酶与治疗药物监测
Ther Drug Monit. 1996 Aug;18(4):393-6. doi: 10.1097/00007691-199608000-00014.
5
Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4, to the hepatic metabolism of the proteasome inhibitor bortezomib.五种主要的人类细胞色素P450,即1A2、2C9、2C19、2D6和3A4,对蛋白酶体抑制剂硼替佐米肝脏代谢的相对贡献。
Drug Metab Dispos. 2005 Nov;33(11):1723-8. doi: 10.1124/dmd.105.005710. Epub 2005 Aug 15.
6
Involvement of CYP3A4 in the metabolism of bromperidol in vitro.
Pharmacol Toxicol. 2000 Mar;86(3):145-8. doi: 10.1034/j.1600-0773.2000.d01-27.x.
7
Increased incidence of anti-LKM autoantibodies in a consecutive cohort of hepatitis C patients from central Greece.希腊中部丙型肝炎患者连续队列中抗肝肾微粒体自身抗体发生率增加。
Eur J Gastroenterol Hepatol. 2002 Jan;14(1):35-42. doi: 10.1097/00042737-200201000-00007.
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Recent advances: the cytochrome P450 enzymes.最新进展:细胞色素P450酶
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9
In vitro metabolism of the calmodulin antagonist DY-9760e (3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate) by human liver microsomes: involvement of cytochromes p450 in atypical kinetics and potential drug interactions.钙调蛋白拮抗剂DY-9760e(3-[2-[4-(3-氯-2-甲基苯基)-1-哌嗪基]乙基]-5,6-二甲氧基-1-(4-咪唑基甲基)-1H-吲唑二盐酸盐3.5水合物)在人肝微粒体中的体外代谢:细胞色素P450参与非典型动力学及潜在药物相互作用
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Two cytochromes P450 are major hepatocellular autoantigens in autoimmune polyglandular syndrome type 1.两种细胞色素P450是1型自身免疫性多腺体综合征中的主要肝细胞自身抗原。
Gastroenterology. 1998 Feb;114(2):324-8. doi: 10.1016/s0016-5085(98)70484-6.

本文引用的文献

1
Detection of liver-kidney microsomal autoantibodies by radioimmunoassay and their relation to anti-mitochondrial antibodies in inflammatory liver diseases.采用放射免疫分析法检测肝肾微粒体自身抗体及其在炎症性肝病中与抗线粒体抗体的关系。
Clin Exp Immunol. 1984 Sep;57(3):600-8.
2
A new anti-liver-kidney microsome antibody (anti-LKM2) in tienilic acid-induced hepatitis.替尼酸诱导的肝炎中一种新的抗肝肾微粒体抗体(抗-LKM2)
Clin Exp Immunol. 1984 Mar;55(3):561-70.
3
Chronic active hepatitis associated with antiliver/kidney microsome antibody type 1: a second type of "autoimmune" hepatitis.
与1型抗肝肾微粒体抗体相关的慢性活动性肝炎:第二种“自身免疫性”肝炎。
Hepatology. 1987 Nov-Dec;7(6):1333-9. doi: 10.1002/hep.1840070626.
4
Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug.药物性肝炎中出现的人抗内质网自身抗体是针对一种使药物羟基化的人肝细胞色素P-450的。
Proc Natl Acad Sci U S A. 1987 Jan;84(2):551-5. doi: 10.1073/pnas.84.2.551.
5
Human cytochrome P-450 4 mRNA and gene: part of a multigene family that contains Alu sequences in its mRNA.人细胞色素P-450 4 mRNA与基因:一个多基因家族的一部分,其mRNA中含有Alu序列。
Proc Natl Acad Sci U S A. 1986 Sep;83(18):6731-5. doi: 10.1073/pnas.83.18.6731.
6
Genetic polymorphism of human cytochrome P-450 (S)-mephenytoin 4-hydroxylase. Studies with human autoantibodies suggest a functionally altered cytochrome P-450 isozyme as cause of the genetic deficiency.人细胞色素P - 450(S)-美芬妥因4 -羟化酶的基因多态性。用人自身抗体进行的研究表明,一种功能改变的细胞色素P - 450同工酶是遗传缺陷的原因。
Biochemistry. 1987 Dec 15;26(25):8466-74. doi: 10.1021/bi00399a065.
7
Identification and analysis of the major M2 autoantigens in primary biliary cirrhosis.原发性胆汁性肝硬化中主要M2自身抗原的鉴定与分析。
Proc Natl Acad Sci U S A. 1988 Nov;85(22):8654-8. doi: 10.1073/pnas.85.22.8654.
8
Antibodies against human cytochrome P-450db1 in autoimmune hepatitis type II.II型自身免疫性肝炎中针对人细胞色素P-450db1的抗体。
Proc Natl Acad Sci U S A. 1988 Nov;85(21):8256-60. doi: 10.1073/pnas.85.21.8256.
9
Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.异喹胍代谢缺陷人类常见遗传缺陷的特征分析。
Nature. 1988 Feb 4;331(6155):442-6. doi: 10.1038/331442a0.
10
Characterisation of a new subgroup of autoimmune chronic active hepatitis by autoantibodies against a soluble liver antigen.通过针对可溶性肝抗原的自身抗体对自身免疫性慢性活动性肝炎一个新亚组的特征描述。
Lancet. 1987 Feb 7;1(8528):292-4. doi: 10.1016/s0140-6736(87)92024-1.