氧化铈纳米颗粒对血管内皮细胞炎症的影响。
Effect of cerium oxide nanoparticles on inflammation in vascular endothelial cells.
机构信息
Department of Mechanical and Aeronautical Engineering, University of California, Davis, California 95616, USA.
出版信息
Inhal Toxicol. 2009 Jul;21 Suppl 1(Suppl 1):123-30. doi: 10.1080/08958370902942582.
Abstract
Because vascular endothelial cell inflammation is critical in the development of cardiovascular pathology, we hypothesized that direct exposure of human aortic endothelial cells (HAECs) to ultrafine particles induces an inflammatory response. To test the hypothesis, we incubated HAECs for 4 h with different concentrations (0.001-50 microg/ml) of CeO(2) nanoparticles and subsequently measured mRNA levels of the three inflammatory markers intercellular adhesion molecule 1 (ICAM-1), interleukin (IL)-8, and monocyte chemotactic protein (MCP-1) using real-time polymerase chain reaction (PCR). Ceria nanoparticles caused very little inflammatory response in HAECs, even at the highest dose. This material is apparently rather benign in comparison with Y(2)O(3) and ZnO nanoparticles that we have studied previously. These results suggest that inflammation in HAECs following acute exposure to metal oxide nanoparticles depends strongly on particle composition.
摘要
由于血管内皮细胞炎症在心血管病理发展中至关重要，我们假设人体主动脉内皮细胞（HAECs）直接暴露于超细颗粒会引发炎症反应。为了验证这一假设，我们将 HAECs 用不同浓度（0.001-50μg/ml）的 CeO2 纳米颗粒孵育 4 小时，然后使用实时聚合酶链反应（PCR）测量三种炎症标志物细胞间黏附分子 1（ICAM-1）、白细胞介素（IL）-8 和单核细胞趋化蛋白（MCP-1）的 mRNA 水平。铈纳米颗粒在 HAECs 中引起的炎症反应很小，即使在最高剂量下也是如此。与我们之前研究过的 Y2O3 和 ZnO 纳米颗粒相比，这种材料显然更为良性。这些结果表明，HAECs 在急性暴露于金属氧化物纳米颗粒后发生的炎症强烈依赖于颗粒成分。
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