Fraser A D, MacNeil W, Isner A F
Toxicology Laboratory, Victoria General Hospital, Nova Scotia, Canada.
J Forensic Sci. 1991 Sep;36(5):1596-602.
A fatality following ingestion of the drug baclofen (Lioresal) is described. Baclofen was identified in urine by gas chromatography/mass spectrometry. After derivatization with trinitrobenzene sulfonic acid, baclofen was quantitated in serum and urine by high-performance liquid chromatography. The concentration of baclofen was 17 mg/L in serum and 760 mg/L in urine collected approximately 12 h after the overdose. To our knowledge, this is only the second reported fatality involving a baclofen overdose. The previous case did not include quantitation of baclofen in any biological fluid.
本文描述了一例因摄入巴氯芬（力奥来素）导致的死亡病例。通过气相色谱/质谱法在尿液中鉴定出了巴氯芬。用三硝基苯磺酸衍生化后，采用高效液相色谱法对血清和尿液中的巴氯芬进行定量。过量服药约12小时后采集的血清中巴氯芬浓度为17mg/L，尿液中为760mg/L。据我们所知，这是第二例报告的因过量服用巴氯芬导致的死亡病例。之前的病例未对任何生物体液中的巴氯芬进行定量。
