Gangavati Anupama S, Kiely Dan K, Kulchycki Lara K, Wolfe Richard E, Mottley J Lawrence, Kelly Sean P, Nathanson Larry A, Abrams Alan P, Lipsitz Lewis A
Department of Medicine, Division of Gerontology, Beth Israel Deaconess Medical Center, Massachusetts 02215, USA.
J Am Geriatr Soc. 2009 Aug;57(8):1470-4. doi: 10.1111/j.1532-5415.2009.02344.x. Epub 2009 Jun 3.
To determine the prevalence and associated characteristics of traumatic intracranial hemorrhage (ICH) in elderly fallers presenting to the emergency department (ED) without focal findings.
Retrospective cohort study.
University-affiliated teaching hospital ED.
Patients aged 65 and older presenting with a fall to the ED and undergoing a head computed tomography (CT) scan.
Electronic medical records and CT scans of 404 consecutive patients were reviewed. Characteristics of patients with and without ICH were compared using unadjusted analyses. Patients taking warfarin, aspirin, or clopidogrel alone or in combination were compared with those not taking these medications. Multivariate logistic regression analyses were performed to determine variables independently associated with ICH.
Forty-seven of 404 elderly fallers (11.6%) without focal findings had an ICH. Unadjusted analyses in these pilot data showed that warfarin was not significantly associated with ICH. Multivariate analyses indicated that elderly people living in at home were more likely to have ICH than those living in nursing homes or assisted living facilities (odds ratio (OR)=3.2, 95% confidence interval (CI)=1.30-8.13) and that those with head trauma were more likely to have ICH than those without (OR=3.9, 95% CI=1.25-7.80). Aspirin was found to be protective (OR=0.49, 95% CI=0.24-0.98).
ICH is common in elderly fallers presenting to the ED without focal findings. Anticoagulation alone did not appear to increase the risk of ICH, and aspirin was found to be protective, but prospective studies are needed to better assess this relationship.
确定在急诊科就诊且无局灶性体征的老年跌倒患者中创伤性颅内出血(ICH)的患病率及相关特征。
回顾性队列研究。
大学附属医院急诊科。
65岁及以上因跌倒至急诊科并接受头部计算机断层扫描(CT)的患者。
回顾了404例连续患者的电子病历和CT扫描结果。采用未校正分析比较有ICH和无ICH患者的特征。将单独或联合使用华法林、阿司匹林或氯吡格雷的患者与未服用这些药物的患者进行比较。进行多变量逻辑回归分析以确定与ICH独立相关的变量。
404例无局灶性体征的老年跌倒患者中有47例(11.6%)发生ICH。这些初步数据的未校正分析表明华法林与ICH无显著相关性。多变量分析表明,与住在养老院或辅助生活设施中的老年人相比,居家生活的老年人发生ICH的可能性更大(比值比(OR)=3.2,95%置信区间(CI)=1.30 - 8.13),且有头部外伤的患者比无头部外伤的患者发生ICH的可能性更大(OR = 3.9,95% CI = 1.25 - 7.80)。发现阿司匹林具有保护作用(OR = 0.49,95% CI = 0.24 - 0.98)。
在急诊科就诊且无局灶性体征的老年跌倒患者中ICH很常见。单独抗凝似乎并未增加ICH风险,且发现阿司匹林具有保护作用,但需要前瞻性研究以更好地评估这种关系。