Department of Internal Medicine I, Regensburg University Hospital, Regensburg, Germany.
Clin Endocrinol (Oxf). 2010 Mar;72(3):342-8. doi: 10.1111/j.1365-2265.2009.03664.x. Epub 2009 Jun 24.
The adipokine chemerin modulates the function of innate immune cells and may link obesity and inflammation, and therefore, a possible relation of chemerin to inflammatory proteins in obesity and type 2 diabetes (T2D) was analysed. As visceral fat contributes to systemic inflammation, chemerin was measured in portal venous (PVS), hepatic venous (HVS) and systemic venous (SVS) blood of patients with liver cirrhosis.
Systemic chemerin was determined by ELISA in the serum of normal-weight, overweight and T2D males, in the serum of T2D patients of both sexes, and in PVS, HVS and SVS of patients with liver cirrhosis.
Circulating chemerin was similar in T2D and obese individuals but was significantly elevated in both cohorts compared to normal-weight individuals. Chemerin positively correlated with leptin, resistin and C-reactive protein (CRP). In T2D, chemerin was similar in male and female patients and increased in patients with elevated CRP. Chemerin was similar in PVS and SVS, indicating that visceral fat is not a major site of chemerin synthesis. Higher levels of chemerin in HVS demonstrate that chemerin is also released by the liver.
Visceral fat is not a major site of chemerin release, and elevated systemic levels of chemerin in obesity and T2D seem to be associated with inflammation rather than body mass index.
脂肪因子趋化素调节先天免疫细胞的功能，可能将肥胖与炎症联系起来，因此分析了趋化素与肥胖和 2 型糖尿病（T2D）中炎症蛋白的可能关系。由于内脏脂肪会导致全身炎症，因此在肝硬化患者的门静脉（PVS）、肝静脉（HVS）和全身静脉（SVS）血中测量了趋化素。
通过 ELISA 法在正常体重、超重和 T2D 男性的血清中、在 T2D 男女患者的血清中以及在肝硬化患者的 PVS、HVS 和 SVS 中测定了系统趋化素。
循环趋化素在 T2D 和肥胖个体中相似，但在这两个队列中均明显高于正常体重个体。趋化素与瘦素、抵抗素和 C 反应蛋白（CRP）呈正相关。在 T2D 中，男女患者的趋化素相似，且 CRP 升高的患者趋化素增加。PVS 和 SVS 中的趋化素相似，表明内脏脂肪不是趋化素合成的主要部位。HVS 中趋化素水平较高表明肝脏也会释放趋化素。
内脏脂肪不是趋化素释放的主要部位，肥胖和 T2D 中全身趋化素水平升高似乎与炎症而非体重指数相关。
