Eisinger Kristina, Krautbauer Sabrina, Wiest Reiner, Weiss Thomas S, Buechler Christa
Department of Internal Medicine I, Regensburg University Hospital, Regensburg, Germany.
Department of Visceral Surgery and Medicine, University Inselspital, Bern, Switzerland.
Exp Mol Pathol. 2015 Apr;98(2):208-13. doi: 10.1016/j.yexmp.2015.01.010. Epub 2015 Jan 13.
Chemerin is a well-established modulator of immune cell function and its serum levels are induced in inflammatory diseases. Liver cirrhosis is associated with inflammation which is aggravated by portal hypertension. The objective of this study was to evaluate whether chemerin is induced in patients with more severe liver cirrhosis and portal hypertension. Chemerin has been measured by ELISA in the portal venous serum (PVS), systemic venous serum (SVS) and hepatic venous serum (HVS) of 45 patients with liver cirrhosis. Chemerin is higher in HVS compared to PVS in accordance with our recently published finding. SVS, HVS and PVS chemerin decline in patients with more advanced liver injury defined by the CHILD-PUGH score. Hepatic chemerin has been determined in a small cohort and is similarly expressed in normal and cirrhotic liver. MELD score and serum markers of liver and kidney function do not correlate with chemerin. There is a positive correlation of chemerin in all compartments with Quick prothrombin time and of SVS chemerin with systolic blood pressure. PVS chemerin is induced in patients with modest/massive ascites but this does not translate into higher HVS and SVS levels. Chemerin is not associated with variceal size. Reduction of portal pressure by transjugular intrahepatic portosystemic shunt does not affect chemerin levels. These data show that low chemerin in patients with more severe liver cirrhosis is associated with reduced Quick prothrombin time.
Chemerin是一种公认的免疫细胞功能调节剂，其血清水平在炎症性疾病中会升高。肝硬化与炎症相关，门静脉高压会加重炎症。本研究的目的是评估在更严重的肝硬化和门静脉高压患者中chemerin是否升高。通过酶联免疫吸附测定法（ELISA）检测了45例肝硬化患者门静脉血清（PVS）、体静脉血清（SVS）和肝静脉血清（HVS）中的chemerin。与我们最近发表的研究结果一致，HVS中的chemerin高于PVS。根据Child-Pugh评分定义，在肝损伤更严重的患者中，SVS、HVS和PVS中的chemerin水平下降。在一个小队列中测定了肝脏chemerin，其在正常肝脏和肝硬化肝脏中的表达相似。终末期肝病模型（MELD）评分以及肝脏和肾脏功能的血清标志物与chemerin无关。所有部位的chemerin与快速凝血酶原时间呈正相关，SVS中的chemerin与收缩压呈正相关。在有轻/大量腹水的患者中PVS中的chemerin升高，但这并未转化为更高的HVS和SVS水平。chemerin与静脉曲张大小无关。经颈静脉肝内门体分流术降低门静脉压力并不影响chemerin水平。这些数据表明，在更严重的肝硬化患者中，低水平的chemerin与快速凝血酶原时间缩短有关。
