Hu Ting-Jun, Shuai Xue-Hong, Chen Jiong-Ran, Wei Ying-Yi, Zheng Rong-Liang
College of Animal Science and Technology, Guangxi University, 530005 Nanning, PR China.
Int J Biol Macromol. 2009 Oct 1;45(3):279-83. doi: 10.1016/j.ijbiomac.2009.06.011. Epub 2009 Jun 24.
Potentilla anserine polysaccharide (PAP) was studied in vivo to investigate its antioxidant activity using the model of dexamethasone-induced oxidative stress in mice. The investigation demonstrated that PAP at 50, 100 or 200mg/kg body weight for 7 days respectively increased thymus index and spleen index, glutathione level, superoxidase dismutase activity and total antioxidant capacity in both thymus and spleen and decreased the content of H(2)O(2) in spleen and NO in both thymus and spleen of mice. The results revealed that PAP was able to overcome dexamethasone-induced oxidative stress and might play an important role in repairs of oxidative damage in immunological system.
以地塞米松诱导的小鼠氧化应激模型对鹅绒委陵菜多糖（PAP）进行体内研究，以考察其抗氧化活性。研究表明，分别以50、100或200mg/kg体重的PAP连续给药7天，可使小鼠胸腺指数和脾脏指数、谷胱甘肽水平、超氧化物歧化酶活性以及胸腺和脾脏中的总抗氧化能力均升高，并降低脾脏中H₂O₂的含量以及胸腺和脾脏中一氧化氮的含量。结果显示，PAP能够对抗地塞米松诱导的氧化应激，可能在免疫系统氧化损伤修复中发挥重要作用。
