Wirtz-Peitz Frederik, Zallen Jennifer A
Developmental Biology Program, Sloan-Kettering Institute, New York, NY 10065, USA.
Curr Opin Genet Dev. 2009 Aug;19(4):350-6. doi: 10.1016/j.gde.2009.04.011. Epub 2009 Jun 24.
Epithelial monolayers are major determinants of three-dimensional tissue organization and provide the structural foundation for the body plan and all of its component organs. Epithelial cells are connected by junctional complexes containing the cell adhesion molecule E-cadherin. Adherens junctions mediate stable cohesion between cells but must be actively reorganized to allow tissue remodeling during development. Recent studies demonstrate that junctional proteins are dynamically turned over at the cell surface, even in cells that do not appear to be moving. The redistribution of E-cadherin through spatially regulated endocytosis and exocytosis contributes to cell adhesion, cell polarity, and cell rearrangement. Here we describe recent progress in understanding the roles of the vesicle transport machinery in regulating cell adhesion and junctional dynamics during epithelial morphogenesis in vivo.
上皮单层是三维组织结构的主要决定因素，为身体结构及其所有组成器官提供结构基础。上皮细胞通过含有细胞粘附分子E-钙粘蛋白的连接复合体相连。粘着连接介导细胞间的稳定凝聚，但在发育过程中必须积极重组以允许组织重塑。最近的研究表明，即使在看似不移动的细胞中，连接蛋白也会在细胞表面动态更新。E-钙粘蛋白通过空间调节的内吞作用和外排作用重新分布，有助于细胞粘附、细胞极性和细胞重排。在这里，我们描述了在理解囊泡运输机制在体内上皮形态发生过程中调节细胞粘附和连接动态方面的最新进展。
