激素疗法与骨骼肌力量：一项荟萃分析。
Hormone therapy and skeletal muscle strength: a meta-analysis.
作者信息
Greising Sarah M, Baltgalvis Kristen A, Lowe Dawn A, Warren Gordon L
机构信息
Department of Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis, 55455, USA.
出版信息
J Gerontol A Biol Sci Med Sci. 2009 Oct;64(10):1071-81. doi: 10.1093/gerona/glp082. Epub 2009 Jun 26.
BACKGROUND
Our objective was to perform a systematic review and meta-analysis of the research literature that compared muscle strength in postmenopausal women who were and were not on estrogen-based hormone therapy (HT).
METHODS
Twenty-three relevant studies were found. Effect sizes (ESs) were calculated as the standardized mean difference, and meta-analyses were completed using a random effects model.
RESULTS
HT was found to result in a small beneficial effect on muscle strength in postmenopausal women (overall ES = 0.23; p = .003) that equated to an approximately 5% greater strength for women on HT. Among the 23 studies, various muscle groups were assessed for strength, and those that benefitted the most were the thumb adductors (ES = 1.14; p < .001). Ten studies that compared muscle strength in rodents that were and were not estradiol deficient were also analyzed. The ES for absolute strength was moderate but not statistically significant (ES = 0.44; p = .12), whereas estradiol had a large effect on strength normalized to muscle size (ES = 0.66; p = .03).
CONCLUSION
Overall, estrogen-based treatments were found to beneficially affect strength.
背景
我们的目的是对研究文献进行系统评价和荟萃分析，比较接受和未接受雌激素类激素疗法（HT）的绝经后女性的肌肉力量。
方法
共找到23项相关研究。效应大小（ESs）以标准化均数差计算，并使用随机效应模型完成荟萃分析。
结果
发现HT对绝经后女性的肌肉力量有微小的有益影响（总体ES = 0.23；p = 0.003），这相当于接受HT治疗的女性力量大约提高5%。在这23项研究中，评估了各种肌肉群的力量，受益最大的是拇指内收肌（ES = 1.14；p < 0.001）。还分析了10项比较有或没有雌二醇缺乏的啮齿动物肌肉力量的研究。绝对力量的ES为中等但无统计学意义（ES = 0.44；p = 0.12），而雌二醇对按肌肉大小标准化的力量有很大影响（ES = 0.66；p = 0.03）。
结论
总体而言，发现基于雌激素的治疗对力量有有益影响。
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