Parker Graham C, Acsadi Gyula, Brenner Carol A
Stem Cells Dev. 2009 Jul-Aug;18(6):803-6. doi: 10.1089/scd.2009.1806.edi.
Stem cells are traditionally classified as being either embryonic stem cells (ESCs) or somatic stem cells. Such a designation has now become blurred by the advent of ostensibly pluripotent cells derived from somatic cells, referred to as induced pluripotent stem cells. Mitochondria are the membrane bound organelles that provide the majority of a cell's chemical energy via their production of adenosine triphosphate. Mitochondria are also known to be vital components in many cell processes including differentiation and apoptosis. We are still remarkably uninformed of how mitochondrial function affects stem cell behavior. Reviewed evidence suggests that mitochondrial function and integrity affect stem cell viability, proliferative and differential potential, and lifespan. Mitochondrial status therefore has profound and as yet unexamined implications for the current drive to develop induced pluripotent stem cells as a therapeutic resource.
传统上，干细胞被分为胚胎干细胞（ESC）或成体干细胞。随着源自体细胞的表面多能性细胞（即诱导多能干细胞）的出现，这种分类现在变得模糊不清。线粒体是膜结合细胞器，通过产生三磷酸腺苷为细胞提供大部分化学能量。线粒体在包括分化和凋亡在内的许多细胞过程中也是至关重要的组成部分。我们对线粒体功能如何影响干细胞行为仍然知之甚少。综述证据表明，线粒体功能和完整性会影响干细胞的活力、增殖和分化潜能以及寿命。因此，线粒体状态对于当前将诱导多能干细胞开发为治疗资源的努力具有深远且尚未得到研究的影响。
