碳水化合物摄入量、血脂与载脂蛋白E表型在儿童中显示出相关性。

Carbohydrate intake, serum lipids and apolipoprotein E phenotype show association in children.

作者信息

Ruottinen Soile, Rönnemaa Tapani, Niinikoski Harri, Lagström Hanna, Saarinen Maiju, Pahkala Katja, Kaitosaari Tuuli, Viikari Jorma, Simell Olli

机构信息

Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.

出版信息

Acta Paediatr. 2009 Oct;98(10):1667-73. doi: 10.1111/j.1651-2227.2009.01399.x. Epub 2009 Jun 26.

DOI:10.1111/j.1651-2227.2009.01399.x

PMID:19563454

Abstract

AIM

To study the association between carbohydrate intake and serum lipids in children, and influence of apolipoprotein E phenotype (apoE) on the association.

SUBJECTS/METHODS: A total of 644 children from a prospective, randomized atherosclerosis prevention trial (STRIP) participated in this longitudinal study at age 5 (n = 644), 7 (n = 585) and 9 (n = 550) years. ApoE phenotype, fasting triglyceride, total, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol concentrations and 4-day food records were analysed.

RESULTS

An increase in the total carbohydrate intake by 1 E% (percentage of total daily energy intake) associated with a decrease in HDL cholesterol by 0.006 mmol/L (p < 0.001) when adjusted for saturated, monounsaturated and polyunsaturated fatty acid, age, gender, body mass index and STRIP study group. The inverse association between total carbohydrate intake and HDL cholesterol was evident in children with apoE3 (p < 0.001) or apoE4 (p < 0.001), but not in those with apoE2 (p = 0.78). An increase in total carbohydrate intake by 1 E% increased triglycerides by 0.02 mmol/L (p < 0.001) independently of apoE phenotype, while 1 E% increase in sucrose intake increased triglycerides by 0.01 mmol/L (p < 0.001).

CONCLUSION

Carbohydrate intake has a relatively small effect on serum lipids in children. Children with the apoE3 or E4 but not with E2 phenotype show reduction in HDL cholesterol with increasing carbohydrate intake indicating that genetic and environmental factors interact with children's lipoprotein metabolism.

摘要

目的

研究儿童碳水化合物摄入量与血脂之间的关联，以及载脂蛋白E表型（apoE）对该关联的影响。

对象/方法：共有644名来自一项前瞻性、随机化动脉粥样硬化预防试验（STRIP）的儿童参与了这项纵向研究，他们在5岁（n = 644）、7岁（n = 585）和9岁（n = 550）时参与研究。分析了apoE表型、空腹甘油三酯、总胆固醇、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）胆固醇浓度以及4天的饮食记录。

结果

在对饱和脂肪酸、单不饱和脂肪酸和多不饱和脂肪酸、年龄、性别、体重指数和STRIP研究组进行校正后，总碳水化合物摄入量每增加1 E%（每日总能量摄入量的百分比），HDL胆固醇降低0.006 mmol/L（p < 0.001）。总碳水化合物摄入量与HDL胆固醇之间的负相关在apoE3（p < 0.001）或apoE4（p < 0.001）儿童中明显，但在apoE2儿童中不明显（p = 0.78）。总碳水化合物摄入量每增加1 E%，甘油三酯独立于apoE表型增加0.02 mmol/L（p < 0.001），而蔗糖摄入量每增加1 E%，甘油三酯增加0.01 mmol/L（p < 0.001）。