CTCF：基因组的主要编排者。
CTCF: master weaver of the genome.
作者信息
Phillips Jennifer E, Corces Victor G
机构信息
Department of Biology, Emory University, Atlanta, GA 30322, USA.
出版信息
Cell. 2009 Jun 26;137(7):1194-211. doi: 10.1016/j.cell.2009.06.001.
Abstract
CTCF is a highly conserved zinc finger protein implicated in diverse regulatory functions, including transcriptional activation/repression, insulation, imprinting, and X chromosome inactivation. Here we re-evaluate data supporting these roles in the context of mechanistic insights provided by recent genome-wide studies and highlight evidence for CTCF-mediated intra- and interchromosomal contacts at several developmentally regulated genomic loci. These analyses support a primary role for CTCF in the global organization of chromatin architecture and suggest that CTCF may be a heritable component of an epigenetic system regulating the interplay between DNA methylation, higher-order chromatin structure, and lineage-specific gene expression.
摘要
CTCF是一种高度保守的锌指蛋白，参与多种调控功能，包括转录激活/抑制、绝缘、印记和X染色体失活。在此，我们根据最近全基因组研究提供的机制性见解，重新评估支持这些作用的数据，并强调CTCF在几个发育调控的基因组位点介导的染色体内和染色体间接触的证据。这些分析支持CTCF在染色质结构的全球组织中起主要作用，并表明CTCF可能是调控DNA甲基化、高阶染色质结构和谱系特异性基因表达之间相互作用的表观遗传系统的可遗传成分。
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Cutting edge: developmental stage-specific recruitment of cohesin to CTCF sites throughout immunoglobulin loci during B lymphocyte development.前沿：在B淋巴细胞发育过程中，黏连蛋白在免疫球蛋白基因座的CTCF位点上呈现发育阶段特异性募集。
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CTCF-dependent enhancer-blocking by alternative chromatin loop formation.通过替代性染色质环形成实现的CTCF依赖性增强子阻断
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