Williams Adam, Flavell Richard A
Department of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA.
J Exp Med. 2008 Apr 14;205(4):747-50. doi: 10.1084/jem.20080066. Epub 2008 Mar 17.
The spatial organization of the genome is thought to play an important part in the coordination of gene regulation. New techniques have been used to identify specific long-range interactions between distal DNA sequences, revealing an ever-increasing complexity to nuclear organization. CCCTC-binding factor (CTCF) is a versatile zinc finger protein with diverse regulatory functions. New data now help define how CTCF mediates both long-range intrachromosomal and interchromosomal interactions, and highlight CTCF as an important factor in determining the three-dimensional structure of the genome.
基因组的空间组织被认为在基因调控的协调中起着重要作用。新技术已被用于识别远端DNA序列之间特定的长程相互作用，揭示了核组织日益增加的复杂性。CCCTC结合因子（CTCF）是一种具有多种调节功能的多功能锌指蛋白。新数据现在有助于确定CTCF如何介导长程染色体内和染色体间相互作用，并突出CTCF作为决定基因组三维结构的重要因素。
