López-Trascasa M, Martín-Villa J M, Vicario J L, Marín M A, Martínez-Ara J, García-Messeguer M C, Arnáiz-Villena A, Fontán G
Immunology Unit, Hospital La Paz, Madrid, Spain.
Nephron. 1991;59(2):261-5. doi: 10.1159/000186562.
C3 nephritic factor (NEF) has been found in 3 siblings presenting different (or none) degrees of renal disease. Other relatives, including their dead father, suffered from a renal illness. In 2 of the siblings, NEF activity was restricted to IgG1 and IgG3 subclasses. Familial NEF incidence and a shared C3 allotype and a common HLA haplotype including BfS alleles for the 3 NEF-positive siblings suggest that at least in our cases genetical factors may be involved in NEF generation.
在3名患有不同程度（或无）肾脏疾病的兄弟姐妹中发现了C3肾炎因子（NEF）。其他亲属，包括他们已故的父亲，都患有肾脏疾病。在其中2名兄弟姐妹中，NEF活性仅限于IgG1和IgG3亚类。家族性NEF发病率以及3名NEF阳性兄弟姐妹共享的C3同种异型和包括BfS等位基因的常见HLA单倍型表明，至少在我们的病例中，遗传因素可能参与了NEF的产生。
