Leslie M D, Dische S
Marie Curie Research Wing, Mount Vernon Centre for Cancer Treatment, Mount Vernon Hospital, Northwood, Middlesex, U.K.
Radiother Oncol. 1991 Oct;22(2):133-9. doi: 10.1016/0167-8140(91)90009-6.
The function of the parotid glands in patients treated by three different schedules of radiotherapy was studied 9 months or more after its conclusion. All had received radiotherapy for a malignancy confined to one side of the head and neck region and only the gland on the side of the lesion was in the treatment volume; the contralateral gland acted as an internal control. Saliva was selectively collected from the parotid glands and the stimulated flow rate and pH of the saliva determined. Flow rates were expressed in each case as a percentage of that of the contralateral ("untreated") gland. Twelve glands that had received conventionally fractionated radiotherapy to a dose of 60-66 Gy showed a mean percentage flow of 20% and a significant fall in the pH of the saliva produced. Six glands that had received CHART and eight conventionally fractionated radiotherapy to a dose of 35-40 Gy showed mean percentage flows of 57 and 65%, respectively, with only slight and non-significant falls in saliva pH. The results show that in the treatment of squamous cell carcinoma in the head and neck the use of CHART can lead to considerably less late change in the function of the parotid gland.
在放疗结束9个月或更长时间后，对接受三种不同放疗方案治疗的患者腮腺功能进行了研究。所有患者均因局限于头颈部一侧的恶性肿瘤接受放疗，且仅病变侧的腺体在治疗范围内；对侧腺体作为内部对照。从腮腺中选择性收集唾液，并测定唾液的刺激流速和pH值。每种情况下的流速均以对侧（“未治疗”）腺体的流速百分比表示。接受60 - 66 Gy常规分割放疗的12个腺体，唾液平均流速百分比为20%，所产生唾液的pH值显著下降。接受加速超分割放疗（CHART）的6个腺体和接受35 - 40 Gy常规分割放疗的8个腺体，唾液平均流速百分比分别为57%和65%，唾液pH值仅略有下降且无显著差异。结果表明，在头颈部鳞状细胞癌的治疗中，使用加速超分割放疗可使腮腺功能的晚期变化显著减少。
