放疗对头颈癌患者腮腺唾液生化成分的影响。
Effects of radiotherapy on parotid salivary sialochemistry in head and neck cancer patients.
作者信息
Gupta S C, Singla Alok, Singh Mangal, Thaliath B Paul, Geeta Jaiswal
机构信息
Department of ENT and Head and Neck Surgery, M.L.N. Medical College, Allahabad, 211001 UP India.
出版信息
Indian J Otolaryngol Head Neck Surg. 2009 Dec;61(4):286-90. doi: 10.1007/s12070-009-0084-7. Epub 2010 Jan 9.
AIM
To determine the effects of high dose irradiation on parotid salivary sodium and pH concentration at subsequent duration of 1.5, 3 and 6 months following radiotherapy.
MATERIALS AND METHODS
Eighty parotid glands of head and neck cancer patients were irradiated with mean dose of 66 Gy. The stimulated parotid flow (PF) was collected by a cannulation of Stenson's duct followed by analysis of sodium (PF sodium) by Easylyte Sodium/Potassium auto analyzer and pH by litmus narrow band pH paper.
RESULTS
A steep elevation of PF sodium was found in post-RT period after 1.5 months of starting RT followed by gradual increase up to 6 months and pH changed towards acidity.
CONCLUSIONS
A high dose of 66 Gy causes irreversible damage to parotid salivary duct system.
目的
确定高剂量辐射对放疗后1.5、3和6个月后续时间段腮腺唾液钠浓度和pH值的影响。
材料与方法
对头颈部癌患者的80个腮腺进行平均剂量为66 Gy的照射。通过斯滕森导管插管收集刺激后的腮腺流量（PF），随后使用Easylyte钠/钾自动分析仪分析钠（PF钠），并用石蕊窄带pH试纸分析pH值。
结果
在开始放疗1.5个月后的放疗后时期，PF钠急剧升高，随后逐渐升高直至6个月，且pH值向酸性变化。
结论
66 Gy的高剂量对腮腺唾液导管系统造成不可逆损伤。
Zotero 插件