Leslie M D, Dische S
Mount Vernon Centre for Cancer Treatment, Northwood, Middlesex, UK.
Radiother Oncol. 1994 Jan;30(1):26-32. doi: 10.1016/0167-8140(94)90006-x.
The salivary gland function of 47 patients treated by radical radiotherapy (CHART or conventionally fractionated treatment) for head and neck cancer has been studied before, during and for up to 12 weeks from the start of treatment. Pronounced falls in salivary flow and pH are seen once radiotherapy has commenced, particularly when both parotid glands are included in the treatment volume. The initial rate of reduction in flow reflects the rate of delivery of treatment. The parotid glands show the greatest sensitivity to radiotherapy compared with the other salivary glands and reduction in salivary flow is dependent on both dose and the proportion of the gland included in the treatment volume. These early changes in salivary gland function are as marked for patients receiving either CHART or conventionally fractionated treatment, so differing from the late changes which have been shown to be less evident after CHART.
对47例接受根治性放疗（加速超分割放疗或常规分割放疗）的头颈癌患者，在治疗前、治疗期间以及从治疗开始起长达12周的时间内，对其唾液腺功能进行了研究。放疗一旦开始，唾液流量和pH值就会明显下降，尤其是当双侧腮腺都包含在治疗范围内时。流量的初始降低速率反映了治疗的给予速率。与其他唾液腺相比，腮腺对放疗最为敏感，唾液流量的降低取决于剂量以及治疗范围内所包含腺体的比例。对于接受加速超分割放疗或常规分割放疗的患者，唾液腺功能的这些早期变化同样显著，这与晚期变化不同，晚期变化已表明在加速超分割放疗后不那么明显。
