Córdoba Alicia, Guerrero David, Larrinaga Begoña, Iglesias Maria Eugenia, Arrechea Maria Asunción, Yanguas Juan Ignacio
Department of Pathology, Hospital of Navarra, Pamplona, Spain.
Int J Dermatol. 2009 Jul;48(7):713-7. doi: 10.1111/j.1365-4632.2009.04076.x.
Both trichoblastoma and basal cell carcinoma (BCC) of the skin are characterized morphologically by the proliferation of basaloid cells; however, BCCs are clinically associated with a more aggressive behavior. An accurate diagnosis of these lesions is essential for effective, timely treatment and appropriate therapeutic decisions.
This study includes 40 lesions. Bcl-2 and CD10 immunohistochemistry were performed in all cases and the patterns of expression were analyzed.
Bcl-2 is useful for the detection of BCC with diffuse expression in nests of basaloid cells, but cannot distinguish between BCC with follicular differentiation and trichoblastoma, as both lesions show the same pattern with positive and negative areas. Conversely, CD10 expression can distinguish between trichoblastomas with peritumoral stromal staining and BCCs with epithelial staining. If both stromal and epithelial areas are stained, these cases are classified as BCC with follicular differentiation.
CD10 is useful for distinguishing between BCC with widespread follicular differentiation and trichoblastomas.
皮肤毛母细胞瘤和基底细胞癌（BCC）在形态学上均以基底样细胞增殖为特征；然而，BCC在临床上具有更具侵袭性的行为。准确诊断这些病变对于有效、及时的治疗以及恰当的治疗决策至关重要。
本研究纳入40个病变。对所有病例进行Bcl-2和CD10免疫组织化学检测并分析表达模式。
Bcl-2有助于检测在基底样细胞巢中呈弥漫性表达的BCC，但无法区分具有毛囊分化的BCC和毛母细胞瘤，因为这两种病变均显示相同的阳性和阴性区域模式。相反，CD10表达可区分具有肿瘤周围基质染色的毛母细胞瘤和具有上皮染色的BCC。如果基质和上皮区域均被染色，这些病例被归类为具有毛囊分化的BCC。
CD10有助于区分具有广泛毛囊分化的BCC和毛母细胞瘤。
